Spiro Meroterpenoids from Ganoderma applanatum

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Spiro Meroterpenoids from Ganoderma applanatum
	Luo, Qi1,2 ; Wei, Xiao-Yi 3; Yang, Jing1 ; Luo, Jin-Feng 4; Liang, Rui 4; Tu, Zheng-Chao 4; Cheng, Yong-Xian 1
刊名	JOURNAL OF NATURAL PRODUCTS
	2017
卷号	80 期号:1 页码:61-70
英文摘要	Spiroapplanatumines A-Q (1-12, 14-16, 18, and 20), new spiro meroterpenoids respectively bearing a 6/5/7 or 6/5/5 ring system, along with three known compounds, spirolingzhines A, B, and D, were isolated from the fruiting bodies of the fungus Ganoderma applanatum. Their structures including absolute configurations were assigned by using spectroscopic methods, ECD and C-13 NMR calculations, and single-crystal X-ray diffraction analysis. Biological evaluation of all the compounds disclosed that compounds 7 and 8 inhibited JAK3 kinase with IC50 values of 7.0 +/- 3.2 and 34.8 +/- 21.1 mu M, respectively.
类目[WOS]	Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]	Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]	INHIBITORS ; METABOLITES ; LUCIDUM ; DISCOVERY ; COCHLEAR ; LINGZHI ; POTENT ; JAK3
收录类别	SCI
语种	英语
WOS记录号	WOS:000393089600009
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/41899]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, South China Bot Garden, Guangzhou 510650, Guangdong, Peoples R China 4.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Peoples R China
推荐引用方式 GB/T 7714	Luo, Qi,Wei, Xiao-Yi,Yang, Jing,et al. Spiro Meroterpenoids from Ganoderma applanatum[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(1):61-70.
APA	Luo, Qi.,Wei, Xiao-Yi.,Yang, Jing.,Luo, Jin-Feng.,Liang, Rui.,...&Cheng, Yong-Xian.(2017).Spiro Meroterpenoids from Ganoderma applanatum.JOURNAL OF NATURAL PRODUCTS,80(1),61-70.
MLA	Luo, Qi,et al."Spiro Meroterpenoids from Ganoderma applanatum".JOURNAL OF NATURAL PRODUCTS 80.1(2017):61-70.