Association Between the MTHFR C677T Polymorphism and Recurrent Pregnancy Loss: A Meta-Analysis

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	Association Between the MTHFR C677T Polymorphism and Recurrent Pregnancy Loss: A Meta-Analysis
	Wu XM 1; Zhao LJ 1; Luo Y[]1; Zhu H 1; He DJ 1; Tang WR[]1,2
刊名	GENETIC TESTING AND MOLECULAR BIOMARKERS
	2012
卷号	16 期号:7 页码:806-811
通讯作者	yingluo@kmust.edu.cn ; twr@sina.com
英文摘要	Background: C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) has been associated with recurrent pregnancy loss (RPL). However, results were conflicting. The aim of this study was to quantitatively summarize the evidence for MTHFR C677T polymorphism and RPL risk. Methods: Electronic search of PubMed and the Chinese Biomedicine database was conducted to select studies. Case-control studies containing available genotype frequencies of C677T were chosen, and odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association. Results: The case-control studies including 2427 cases and 3118 controls were identified. The meta-analysis stratified by ethnicity showed that individuals with the homozygous TT genotype had increased risk of RPL (OR = 1.574, 95% CI: 1.163-2.13, p = 0.003), in Asians (OR = 1.663, 95% CI: 1.012-2.731, p = 0.045). Results among Caucasians did not suggest an association (OR = 1.269, 95% CI: 0.914-1.761, p = 0.155). A symmetric funnel plot, the Egger's test (p = 0.285), and the Begg's test (p = 0.529) were all suggestive of the lack of publication bias. The studies conducted in each of the defined number of pregnancy losses-two or more pregnancy losses, and three or more pregnancy losses-showed no effect of the C677T polymorphism on RPL except for the TT versus CT + CT genotype comparison for the three or more pregnancy loss subgroup (OR = 1.792, 95% CI: 1.187-2.704, p = 0.005). Conclusion: This meta-analysis supports the idea that MTHFR C677T genotype is associated with increased risk of RPL, except for Caucasians. To draw comprehensive and true conclusions, further prospective studies with larger numbers of participants worldwide are needed to examine associations between MTHFR C677T polymorphism and RPL.
资助信息	This work was financially supported by the National Nat- ure Science Foundation of China (No. 30960152, 30871232, and 31170735), the Nature Science Foundation of Yunnan Province (No. 2008C043M), and the Fund of State Key Labora- tory of Genetics Resources and Evolution (No. GREKF10-07).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/11062]
专题	昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_基因起源组
作者单位	1.Lab of Molecular Genetics of Aging and Tumor, Faculty of Life Science and Technology and Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan, China. 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
推荐引用方式 GB/T 7714	Wu XM,Zhao LJ,Luo Y[*],et al. Association Between the MTHFR C677T Polymorphism and Recurrent Pregnancy Loss: A Meta-Analysis[J]. GENETIC TESTING AND MOLECULAR BIOMARKERS,2012,16(7):806-811.
APA	Wu XM,Zhao LJ,Luo Y[],Zhu H,He DJ,&Tang WR[].(2012).Association Between the MTHFR C677T Polymorphism and Recurrent Pregnancy Loss: A Meta-Analysis.GENETIC TESTING AND MOLECULAR BIOMARKERS,16(7),806-811.
MLA	Wu XM,et al."Association Between the MTHFR C677T Polymorphism and Recurrent Pregnancy Loss: A Meta-Analysis".GENETIC TESTING AND MOLECULAR BIOMARKERS 16.7(2012):806-811.