| 新的肺癌相关基因MCRS1病理生理功能研究 | |
| 刘敏霞; 周可成; 曹毅 | |
| 2014 | |
| 会议名称 | 第十六届中国科协年会——分3环境污染及职业暴露与人类癌症学术研讨会 |
| 会议日期 | 2014-05-24 |
| 会议地点 | 中国云南昆明 |
| 关键词 | 非小细胞肺癌 微小球蛋白1 细胞增殖 上皮-间充质转化 |
| 其他题名 | Pathophysiological Function of Oncogenic MCRS1 in Non-Small Cell Lung Cancer |
| 中文摘要 | 肺癌是一种常见的恶性肿瘤。随着吸烟和环境污染影响的增加,肺癌的发病率和病死率均迅速上升。在前期工作中,结合细胞遗传学和分子遗传学方法,对肺癌细胞系进行染色体分析,发现12q13区域异常。免疫组织化学染色和免疫印迹分析进一步证实,MCRS1蛋白水平在肺癌细胞和组织也确有升高。MCRS1定位于细胞核,参与基因转录调节、细胞转化和恶性肿瘤发生及发展等过程。基于MCRS1在非小细胞肺癌中异常表达,应用RN 更多还原 |
| 英文摘要 | Lung cancer is the most common type of cancer in the world. With the increase of smoking and environment pollution, the morbidity and mortality rate of lung cancer are growing rapidly. Previously, we showed, using karyotypic and loss of heterozygosity (LOH) analyses, that chromosome arm 12q abnormalities occurred in NSCLCs. Subsequently, overexpression of microspherule protein 1(MCRS1) was confirmed at the protein level in tissues and cultured cells of lung cancer by immunostaining and Western blot. MCRS1 is localized to the nucleus with known roles in transcription regulation, cellular transformation, and tumorigenesis. As MCRS1 overexpression in NSCLCs, we investigated its roles in NSCLC by RNAi and examined tumor growth, migration and invasion. These findings suggested that MCRS1 could play vital roles in the development and progression of lung cancer. Altogether, these results indicated that MCRS1 maybe a new lung cancer related gene. These findings provided a comprehesive understanding of MCRS1 pathophysiological functions in the development and progression of NSCLC, and more research on the mechnisms are badly needed. |
| 会议录出版者 | 中国科学技术协会学会学术部 |
| 语种 | 中文 |
| 内容类型 | 会议论文 |
| 源URL | [http://159.226.149.26:8080/handle/152453/11157]  |
| 专题 | 昆明动物研究所_分子病理学 |
| 作者单位 | 中国科学院昆明动物研究所 |
| 推荐引用方式 GB/T 7714 | 刘敏霞,周可成,曹毅. 新的肺癌相关基因MCRS1病理生理功能研究[C]. 见:第十六届中国科协年会——分3环境污染及职业暴露与人类癌症学术研讨会. 中国云南昆明. 2014-05-24. |
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