TET3-mediated DNA oxidation promotes ATR-dependent DNA damage response

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	TET3-mediated DNA oxidation promotes ATR-dependent DNA damage response
	Jiang DW 1; Wei S 1,2; Chen F 1; Zhang Y 1; Li JL[*]1,3
刊名	EMBO reports
	2017
卷号	期号:页码:Published online
关键词	5hmC ATR DNA damage response DNA demethylation TET3
通讯作者	lijiali@mail.kiz.ac.cn
英文摘要	An efficient, accurate, and timely DNA damage response (DDR) is crucial for the maintenance of genome integrity. Here, we report that ten-eleven translocation dioxygenase (TET) 3-mediated conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in response to ATR-dependent DDR regulates DNA repair. ATR-dependent DDR leads to dynamic changes in 5hmC levels and TET3 enzymatic activity. We show that TET3 is an ATR kinase target that oxidizes DNA during ATR-dependent DNA damage repair. Modulation of TET3 expression and activity affects DNA damage signaling and DNA repair and consequently cell death. Our results provide novel insight into ATR-mediated DDR, in which TET3-mediated DNA demethylation is crucial for efficient DNA repair and maintenance of genome stability.
收录类别	SCI
资助信息	This work was supported by the Chinese Academy of Sciences (Y406541141 and 1100050210) to J.L. and the National Science Foundation of China (NSFC 81471313 and 91649119) to J.L.
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/11033]
专题	昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_表观遗传与神经退行性疾病昆明动物研究所_中国科学院昆明灵长类研究中心
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China 3.Kunming Primate Research Center of the Chinese Academy of Sciences, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, China
推荐引用方式 GB/T 7714	Jiang DW,Wei S,Chen F,et al. TET3-mediated DNA oxidation promotes ATR-dependent DNA damage response[J]. EMBO reports,2017,():Published online.
APA	Jiang DW,Wei S,Chen F,Zhang Y,&Li JL[].(2017).TET3-mediated DNA oxidation promotes ATR-dependent DNA damage response.EMBO reports,(*),Published online.
MLA	Jiang DW,et al."TET3-mediated DNA oxidation promotes ATR-dependent DNA damage response".EMBO reports .(2017):Published online.