Fabrication of large diameter TiO2 nanotube for bone morphogenetic protein-2 delivery | |
Liang, Kun1; Li XC(李小成)2; Beng Kang Tay1 | |
刊名 | International Journal of Nanotechnology |
2014 | |
卷号 | 11期号:12页码:1097-1109 |
关键词 | TiO2 nanotube titanium dioxide large diameter anodisation electrochemical BMP-2 delivery protein elution nanotechnology |
ISSN号 | 1475-7435 |
通讯作者 | Liang, Kun |
英文摘要 | A localised and release-controlled carrier is essential to enhance the effectiveness of bone morphogenetic protein in bone regeneration and repair. In this work, TiO2 nanotubes with diameter larger than 350 nm were successfully fabricated for the first time by electrochemical method using diethylene glycol electrolyte. The diameter of the nanotubes reaches 550 nm and 680 nm at 90 V and 100 V, respectively. Their influences for bone morphogenetic protein-2 (BMP-2) delivery were investigated. In the study of protein release, fabricated TiO2 nanotubes have shown superhydrophilic properties that induce tight interaction with BMP-2. The release profile of the TiO2 nanotubes demonstrated a larger retention of protein, a more significant suppression of the initial burst and a better retardation of the release rate. Elution profile was also found to be dependent greatly on the density and the diameter of the nanotubes. Results have shown that the initial burst was larger for nanotubes with lower density and more proteins were released from nanotubes with larger diameter for the whole elution process. |
学科主题 | 材料科学与物理化学 |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000345815300009 |
内容类型 | 期刊论文 |
源URL | [http://210.77.64.217/handle/362003/21325] |
专题 | 兰州化学物理研究所_清洁能源化学与材料实验室 |
作者单位 | 1.Nanyang Technol Univ, Nanoelect Ctr Excellence, Sch Elect & Elect Engn, NOVITAS, Singapore 639798, Singapore 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Lab Clean Energy Chem & Mat, Lanzhou 730000, Peoples R China |
推荐引用方式 GB/T 7714 | Liang, Kun,Li XC,Beng Kang Tay. Fabrication of large diameter TiO2 nanotube for bone morphogenetic protein-2 delivery[J]. International Journal of Nanotechnology,2014,11(12):1097-1109. |
APA | Liang, Kun,Li XC,&Beng Kang Tay.(2014).Fabrication of large diameter TiO2 nanotube for bone morphogenetic protein-2 delivery.International Journal of Nanotechnology,11(12),1097-1109. |
MLA | Liang, Kun,et al."Fabrication of large diameter TiO2 nanotube for bone morphogenetic protein-2 delivery".International Journal of Nanotechnology 11.12(2014):1097-1109. |
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