Copper-doped mesoporous silica nanospheres, a promising immunomodulatory agent for inducing osteogenesis | |
Shi, Mengchao1,5; Chen, Zetao2,5; Farnaghi, Saba2,5; Friis, Thor2,5; Mao, Xueli3,4,5; Xiao, Yin2,5; Wu, Chengtie1,5 | |
刊名 | ACTA BIOMATERIALIA
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2016-01-15 | |
卷号 | 30页码:334-344 |
关键词 | Mesoporous silica nanoparticles Copper Macrophage BMSC Bone repair |
英文摘要 | The application of mesoporous silica nanospheres (MSNs) loaded with drugs/growth factors to induce osteogenic differentiation of stem cells has been trialed by a number of researchers recently. However, limitations such as high cost, complex fabrication and unintended side effects from supraphysiological concentrations of the drugs/growth factors represent major obstacles to any potential clinical application in the near term. In this study we reported an in situ one-pot synthesis strategy of MSNs doped with hypoxia-inducing copper ions and systematically evaluated the nanospheres by in vitro biological assessments. The Cu-containing mesoporous silica nanospheres (Cu-MSNs) had uniform spherical morphology (similar to 100 nm), ordered mesoporous channels (similar to 2 nm) and homogeneous Cu distribution. Cu-MSNs demonstrated sustained release of both silicon (Si) and Cu ions and controlled degradability. The Cu-MSNs were phagocytized by immune cells and appeared to modulate a favorable immune environment by initiating proper pro-inflammatory cytokines, inducing osteogenic/angiogenic factors and suppressing osteoclastogenic factors by the immune cells. The immune microenvironment induced by the Cu-MSNs led to robust osteogenic differentiation of bone mesenchymal stem cells (BMSCs) via the activation of Oncostation M (OSM) pathway. These results suggest that the novel Cu-MSNs could be used as an immunomodulatory agent with osteostimulatory capacity for bone regeneration/therapy application. |
WOS标题词 | Science & Technology ; Technology |
类目[WOS] | Engineering, Biomedical ; Materials Science, Biomaterials |
研究领域[WOS] | Engineering ; Materials Science |
关键词[WOS] | BETA-TRICALCIUM PHOSPHATE ; MESENCHYMAL STEM-CELLS ; BIOACTIVE GLASS SCAFFOLDS ; DELIVERY-SYSTEM ; IN-VIVO ; ANTIBACTERIAL ACTIVITY ; BONE-RESORPTION ; DRUG-DELIVERY ; NANOPARTICLES ; RELEASE |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000368563600030 |
内容类型 | 期刊论文 |
源URL | [http://ir.sic.ac.cn/handle/331005/23272] ![]() |
专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Queensland Univ Technol, Inst Hlth & Biomed Innovat, 60 Musk Ave, Brisbane, Qld 4059, Australia 3.Sun Yat Sen Univ, Hosp Stomatol, Guangdong Prov Key Lab Stomatol, 56 Ling Yuan Rd West, Guangzhou 510055, Guangdong, Peoples R China 4.Sun Yat Sen Univ, Hosp Stomatol, Guanghua Sch Stomatol, 56 Ling Yuan Rd West, Guangzhou 510055, Guangdong, Peoples R China 5.Queensland Univ Technol, Australia China Ctr Tissue Engn & Regenerat Med, 60 Musk Ave, Brisbane, Qld 4059, Australia |
推荐引用方式 GB/T 7714 | Shi, Mengchao,Chen, Zetao,Farnaghi, Saba,et al. Copper-doped mesoporous silica nanospheres, a promising immunomodulatory agent for inducing osteogenesis[J]. ACTA BIOMATERIALIA,2016,30:334-344. |
APA | Shi, Mengchao.,Chen, Zetao.,Farnaghi, Saba.,Friis, Thor.,Mao, Xueli.,...&Wu, Chengtie.(2016).Copper-doped mesoporous silica nanospheres, a promising immunomodulatory agent for inducing osteogenesis.ACTA BIOMATERIALIA,30,334-344. |
MLA | Shi, Mengchao,et al."Copper-doped mesoporous silica nanospheres, a promising immunomodulatory agent for inducing osteogenesis".ACTA BIOMATERIALIA 30(2016):334-344. |
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