Printable hybrid hydrogel by dual enzymatic polymerization with superactivity | |
Wei, Qingcong1; Xu, Mengchi2; Liao, Chuanan1; Wu, Qing1; Liu, Mingyu3; Zhang, Ye4; Wu, Chengtie2; Cheng, Liming5; Wang, Qigang1 | |
刊名 | CHEMICAL SCIENCE |
2016 | |
卷号 | 7期号:4页码:2748-2752 |
英文摘要 | A new approach has been developed to fabricate tough hybrid hydrogels by employing dual enzyme-mediated redox initiation to achieve post-self-assembly cross-linking polymerization. The resulting hydrogel combines the merits of supramolecular hydrogels with polymeric hydrogels to achieve higher mechanical strength and porous networks. Designed 3D constructs were fabricated via in situ 3D printing. The in situ immobilized GOx/HRP in Gel II exhibited superactivity compared to free enzymes, which might be attributed to the synergistic effect of co-localized GOx and HRP minimizing the distances for mass transport between the gel and the bulk solution. This mechanically strong hybrid hydrogel maintained high reusability and thermal stability as well. In addition, in situ 3D cell culture was demonstrated, thus indicating that this biodegradable hybrid hydrogel is biocompatible with cells. The subsequent 3D cell printing further indicates that the hybrid hydrogel is a promising scaffold for bio-related applications such as biocatalysis and tissue engineering. |
WOS标题词 | Science & Technology ; Physical Sciences |
类目[WOS] | Chemistry, Multidisciplinary |
研究领域[WOS] | Chemistry |
关键词[WOS] | ASSEMBLY CROSS-LINKING ; BIOCATALYTIC PERFORMANCE ; SUPRAMOLECULAR HYDROGEL ; OSCILLATORY HYDROGELS ; MOLECULAR NANOFIBERS ; AQUEOUS-SOLUTION ; ACTIVE GELS ; COPOLYMERS ; SCAFFOLDS ; NETWORKS |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000372614800038 |
内容类型 | 期刊论文 |
源URL | [http://ir.sic.ac.cn/handle/331005/23164] |
专题 | 上海硅酸盐研究所_生物材料与组织工程研究中心_期刊论文 |
作者单位 | 1.Tongji Univ, Dept Chem, Adv Res Inst, Shanghai 200092, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab Performance Ceram & Superfine Micro, Shanghai 200050, Peoples R China 3.Tongji Univ, Sch Life Sci & Technol, Shanghai 200092, Peoples R China 4.Okinawa Inst Sci & Technol, Bioinspired Soft Matter Unit, Onna, Okinawa, Japan 5.Tongji Univ, Sch Med, Tongji Hosp, Spine Div,Orthopaed Dept, Shanghai 200065, Peoples R China |
推荐引用方式 GB/T 7714 | Wei, Qingcong,Xu, Mengchi,Liao, Chuanan,et al. Printable hybrid hydrogel by dual enzymatic polymerization with superactivity[J]. CHEMICAL SCIENCE,2016,7(4):2748-2752. |
APA | Wei, Qingcong.,Xu, Mengchi.,Liao, Chuanan.,Wu, Qing.,Liu, Mingyu.,...&Wang, Qigang.(2016).Printable hybrid hydrogel by dual enzymatic polymerization with superactivity.CHEMICAL SCIENCE,7(4),2748-2752. |
MLA | Wei, Qingcong,et al."Printable hybrid hydrogel by dual enzymatic polymerization with superactivity".CHEMICAL SCIENCE 7.4(2016):2748-2752. |
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