Microwave-activated nanodroplet vaporization for highly efficient tumor ablation with real-time monitoring performance

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 高性能陶瓷和超微结构国家重点实验室 > 期刊论文

	Microwave-activated nanodroplet vaporization for highly efficient tumor ablation with real-time monitoring performance
	Xu, Jinshun 1; Chen, Yu 2; Deng, Liming 1; Liu, Jianxin 1; Cao, Yang 1; Li, Pan 1; Ran, Haitao 1; Zheng, Yuanyi 1; Wang, Zhigang 1
刊名	BIOMATERIALS
	2016-11-01
卷号	106 页码:264-275
关键词	Microwave ablation Imaging guidance Droplet vaporization Synergistic agent Nanotechnology Tumor therapy
英文摘要	The fast development of nanotechnology has provided a new efficient strategy for enhancing the therapeutic efficiency of various treatment modalities against cancer. However, the improvement of minimally invasive microwave therapy based on nanomaterials has not been realized. In this work, we successfully designed and synthesized a novel folate-targeted nanodroplet (TPN) with a composite mixture of perfiuorocarbons as the core and lipid as the shell, which exerts the distinctive dual functions as the adjuvant for highly efficient percutaneous ultrasound imaging-guided microwave ablation (MWA) of tumors. Based on the unique phase-changeable performance of TPN nanosystem, a novel microwave droplet vaporization (MWDV) strategy was proposed, for the first time, to overcome the critical issues of traditional acoustic-droplet vaporization (ADV) and optical-droplet vaporization (ODV) for cancer theranostics. Especially, the elaborately designed TPN can overcome the challenges of indistinct imaging of ablation margin and the limited ablation zone of MWA modality against cancer. The high efficiency of this new MWDV strategy has been systematically elucidated in vitro, ex vivo and in vivo. Therefore, such a successful demonstration of the role of nanomaterials (TPN in this case) in ultrasound imaging-guided MWA therapy against cancer provides a highly feasible strategy to effectively enhance the MWA outcome with the specific features of high efficiency and biosafety. (C) 2016 Elsevier Ltd. All rights reserved.
WOS标题词	Science & Technology ; Technology
类目[WOS]	Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]	Engineering ; Materials Science
关键词[WOS]	INTENSITY FOCUSED ULTRASOUND ; SYNERGISTIC HIFU ABLATION ; RADIOFREQUENCY ABLATION ; HEPATOCELLULAR-CARCINOMA ; IN-VIVO ; CARBON NANOTUBES ; THERMAL ABLATION ; CANCER-THERAPY ; DRUG-DELIVERY ; MICROBUBBLES
收录类别	SCI
语种	英语
WOS记录号	WOS:000383934300022
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/22827]
专题	上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文
作者单位	1.Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing 400010, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Ceram, State Lab High Performance Ceram & Superfine Micr, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	Xu, Jinshun,Chen, Yu,Deng, Liming,et al. Microwave-activated nanodroplet vaporization for highly efficient tumor ablation with real-time monitoring performance[J]. BIOMATERIALS,2016,106:264-275.
APA	Xu, Jinshun.,Chen, Yu.,Deng, Liming.,Liu, Jianxin.,Cao, Yang.,...&Wang, Zhigang.(2016).Microwave-activated nanodroplet vaporization for highly efficient tumor ablation with real-time monitoring performance.BIOMATERIALS,106,264-275.
MLA	Xu, Jinshun,et al."Microwave-activated nanodroplet vaporization for highly efficient tumor ablation with real-time monitoring performance".BIOMATERIALS 106(2016):264-275.