Melodinine V, an antitumor bisindole alkaloid with selective cytotoxicity from Melodinus henryi

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Melodinine V, an antitumor bisindole alkaloid with selective cytotoxicity from Melodinus henryi
	Liu, Ya-Ping 1,5; Yue, Grace Gar-Lee 2,3; Lee, Julia Kin-Ming 2,3; Feng, Tao 4; Zhao, Yun-Li 1,5; Li, Yan1,5 ; Lau, Clara Bik-San 2,3; Luo, Xiao-Dong1,5
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2016-10-15
卷号	26 期号:20 页码:4895-4898
关键词	Melodinine V Bisindole Inhibited cell proliferation Cell cycle arrest Cellular apoptosis HT-29 cells
英文摘要	Melodinine V (1) with a vincanol-eburenine skeleton, was isolated from Melodinus henryi. The structure was elucidated by extensive spectroscopic methods and further confirmed by the single crystal X-ray diffraction analysis. Melodinine V showed selective cytotoxic activities against human colon cancer cell line HT-29 and inhibited cell proliferation in a concentration-dependent manner. It induced cell cycle arrest at G1 phase and cellular apoptosis by increasing histone-associated DNA fragmentation in the treated HT-29 cells. (C) 2016 Elsevier Ltd. All rights reserved.
类目[WOS]	Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]	Pharmacology & Pharmacy ; Chemistry
关键词[WOS]	MONOTERPENOID INDOLE ALKALOIDS ; VINCA ALKALOIDS ; CELL-CULTURES ; SUAVEOLENS ; TENUICAUDATUS ; BIOSYNTHESIS ; VINBLASTINE ; CHEMISTRY ; APOPTOSIS
收录类别	SCI
语种	英语
WOS记录号	WOS:000385498500008
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/33628]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China 3.Chinese Univ Hong Kong, State Key Lab Phytochem & Plant Resources West Ch, Shatin, Hong Kong, Peoples R China 4.South Cent Univ Nationalities, Coll Pharmaceut Sci, Wuhan, Peoples R China 5.Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China
推荐引用方式 GB/T 7714	Liu, Ya-Ping,Yue, Grace Gar-Lee,Lee, Julia Kin-Ming,et al. Melodinine V, an antitumor bisindole alkaloid with selective cytotoxicity from Melodinus henryi[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(20):4895-4898.
APA	Liu, Ya-Ping.,Yue, Grace Gar-Lee.,Lee, Julia Kin-Ming.,Feng, Tao.,Zhao, Yun-Li.,...&Luo, Xiao-Dong.(2016).Melodinine V, an antitumor bisindole alkaloid with selective cytotoxicity from Melodinus henryi.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(20),4895-4898.
MLA	Liu, Ya-Ping,et al."Melodinine V, an antitumor bisindole alkaloid with selective cytotoxicity from Melodinus henryi".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.20(2016):4895-4898.