Gadolinium functionalized carbon dots for fluorescence/magnetic resonance dual-modality imaging of mesenchymal stem cells

CORC > 苏州纳米技术与纳米仿生研究所 > 中国科学院苏州纳米技术与纳米仿生研究所 > 纳米生物医学与安全研究部 > 张智军团队

	Gadolinium functionalized carbon dots for fluorescence/magnetic resonance dual-modality imaging of mesenchymal stem cells
	Chen, Hao; Wang, Lina; Fu, Han; Wang, Zhiying; Xie, Yujie; Zhang, Zhijun(张智军); Tang, Yu
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2016
卷号	4 期号:46
通讯作者	Tang, Y ; Zhang, Zhijun(张智军)
英文摘要	The development of multimodal nanoprobes is of great importance in nanomedicine because it integrates the advantages of each imaging modality and offers a significantly enhanced diagnostic effect. In this work, gadolinium(III) functionalized fluorescent carbon dots (Gd-CDs) are synthesized by means of a one-step hydrothermal approach. As a fluorescent nanomaterial, the obtained Gd-CDs exhibit strong and stable fluorescence with excitation-independent emission behavior. Moreover, as an MRI contrast agent, the Gd-CDs exhibited a longitudinal relaxation rate of 6.06 mM(-1) s(-1), which is significantly higher than that of the commercially available MRI agent Gadovist (4.24 mM(-1) s(-1)). In addition, the cellular experiment reveals that Gd-CDs promote the proliferation of human mesenchymal stem cells (hMSCs), which is tracked by the fluorescence/Magnetic Resonance dual-modality imaging of hMSCs by the Gd-CDs.
关键词[WOS]	GRAPHENE QUANTUM DOTS ; NEPHROGENIC SYSTEMIC FIBROSIS ; MRI CONTRAST AGENTS ; IN-VIVO ; SURFACE-STATE ; ENDOTHELIAL-CELLS ; CANCER-THERAPY ; DRUG-DELIVERY ; NANODOTS ; FLUORESCENT
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000389666000015
内容类型	期刊论文
源URL	[http://ir.sinano.ac.cn/handle/332007/4922]
专题	苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_张智军团队
推荐引用方式 GB/T 7714	Chen, Hao,Wang, Lina,Fu, Han,et al. Gadolinium functionalized carbon dots for fluorescence/magnetic resonance dual-modality imaging of mesenchymal stem cells[J]. JOURNAL OF MATERIALS CHEMISTRY B,2016,4(46).
APA	Chen, Hao.,Wang, Lina.,Fu, Han.,Wang, Zhiying.,Xie, Yujie.,...&Tang, Yu.(2016).Gadolinium functionalized carbon dots for fluorescence/magnetic resonance dual-modality imaging of mesenchymal stem cells.JOURNAL OF MATERIALS CHEMISTRY B,4(46).
MLA	Chen, Hao,et al."Gadolinium functionalized carbon dots for fluorescence/magnetic resonance dual-modality imaging of mesenchymal stem cells".JOURNAL OF MATERIALS CHEMISTRY B 4.46(2016).