Biodegradable Poly(aminoester)-Mediated p53 Gene Delivery for Cancer Therapy

CORC > 苏州纳米技术与纳米仿生研究所 > 中国科学院苏州纳米技术与纳米仿生研究所 > 纳米生物医学与安全研究部 > 张智军团队

	Biodegradable Poly(aminoester)-Mediated p53 Gene Delivery for Cancer Therapy
	Shen, H(沈贺); Liu, M(刘敏); Zhang, ZJ(张智军)
刊名	JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
	2016
卷号	16 期号:3 页码:2210-2217
通讯作者	Zhang, ZJ(张智军)
英文摘要	Gene therapy is a promising strategy in cancer treatment. However, efficient gene translation still remains challenging. In the previous work, a hydrolytically degradable poly(aminoester) with good biocompatibility was synthesized. Herein, the poly(aminoester) was explored as a vector for gene delivery and cancer therapy. The experiments revealed that the poly(aminoester) condensed plasmid DNA into nanosized particles via electrostatic interaction. The pEGFP-N1 and pGL-3 were first used as two reporter genes to study intracellular transfection. The poly(aminoester) showed higher GFP expression (33%) than PEI 25 kDa (21%). Intracellular trafficking of Cy3-labelled pGL-3 also indicated that the poly(aminoester) showed superior DNA delivery ability to nucleus compared to PEI 25 kDa. Furthermore, the therapeutic gene (p53) was translated into the breast cancer cell line (MCF-7), and then induced cell apoptosis. These results suggested that the degradable poly(aminoester) is a promising and efficient gene delivery vector for gene therapeutic applications.
关键词[WOS]	ENTRAPPED GOLD NANOPARTICLES ; IN-VITRO ; TRANSFECTION ; POLYETHYLENIMINE ; VECTORS ; PROLIFERATION ; APOPTOSIS ; POLYMERS ; PROTEIN ; CELLS
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000374153800012
内容类型	期刊论文
源URL	[http://ir.sinano.ac.cn/handle/332007/4725]
专题	苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_张智军团队
推荐引用方式 GB/T 7714	Shen, H,Liu, M,Zhang, ZJ. Biodegradable Poly(aminoester)-Mediated p53 Gene Delivery for Cancer Therapy[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016,16(3):2210-2217.
APA	Shen, H,Liu, M,&Zhang, ZJ.(2016).Biodegradable Poly(aminoester)-Mediated p53 Gene Delivery for Cancer Therapy.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,16(3),2210-2217.
MLA	Shen, H,et al."Biodegradable Poly(aminoester)-Mediated p53 Gene Delivery for Cancer Therapy".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 16.3(2016):2210-2217.