Preparation of linear poly(glycerol) as a T-1 contrast agent for tumor-targeted magnetic resonance imaging

CORC > 苏州纳米技术与纳米仿生研究所 > 中国科学院苏州纳米技术与纳米仿生研究所 > 纳米生物医学与安全研究部 > 裴仁军团队

	Preparation of linear poly(glycerol) as a T-1 contrast agent for tumor-targeted magnetic resonance imaging
	Cao, Y(曹翼); Liu, M(刘敏); Zhang, KC(张坤驰); Dong, JJ(董京金); Zu, GY(祖广月); Chen, Y(陈阳); Zhang, TT; Xiong, DS; Pei, RJ(裴仁军)
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2016
卷号	4 期号:41
通讯作者	Pei, RJ(裴仁军)
英文摘要	Macromolecular contrast agents (CAs) labeled with targeting molecules are gaining remarkable interest as promising materials overcoming the defects of small-molecule CAs. Designed on the basis of biocompatible poly(glycerol) (PG), a linear macromolecular contrast agent (CA) was synthesized with a composition of PG as a backbone and partial hydroxyl connected with gadolinium labeled poly(L-lysine) dendrons, where folic acid was also conjugated. This linear CA exhibited higher relaxivity (7.04 mM(-1) S-1) relative to Magnevists (3.98 mM(-1) S-1), and showed negligible toxicity determined by WST assay and histological analysis. In vitro and in vivo magnetic resonance imaging (MRI) measurements presented obvious target specificity to KB cells and tumor. Moreover, high signal enhancement was observed in the tumor region at various time points after intravenous injection to ensure the long time window for imaging. All the findings make it an attractive candidate for tumor-targeted MRI CAs.
关键词[WOS]	CLICK CHEMISTRY ; GADOLINIUM CHELATE ; MRI ; DENDRIMERS ; RELAXIVITY ; DELIVERY ; PHARMACOKINETICS ; MACROMOLECULES ; CYCLODEXTRIN ; POLYGLYCEROL
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000386336300010
内容类型	期刊论文
源URL	[http://ir.sinano.ac.cn/handle/332007/4924]
专题	苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_裴仁军团队
推荐引用方式 GB/T 7714	Cao, Y,Liu, M,Zhang, KC,et al. Preparation of linear poly(glycerol) as a T-1 contrast agent for tumor-targeted magnetic resonance imaging[J]. JOURNAL OF MATERIALS CHEMISTRY B,2016,4(41).
APA	Cao, Y.,Liu, M.,Zhang, KC.,Dong, JJ.,Zu, GY.,...&Pei, RJ.(2016).Preparation of linear poly(glycerol) as a T-1 contrast agent for tumor-targeted magnetic resonance imaging.JOURNAL OF MATERIALS CHEMISTRY B,4(41).
MLA	Cao, Y,et al."Preparation of linear poly(glycerol) as a T-1 contrast agent for tumor-targeted magnetic resonance imaging".JOURNAL OF MATERIALS CHEMISTRY B 4.41(2016).