Targeting the orexinergic system: Mainly but not only for sleep-wakefulness therapies

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 神经系统疾病

	Targeting the orexinergic system: Mainly but not only for sleep-wakefulness therapies
	Ghanemi A[*]1,2; Hu XT 1,3
刊名	Alexandria Journal of Medicine
	2015
卷号	51 期号:X 页码:279–286
关键词	Orexin receptors Sleep-wakefulness therapy Potential target
通讯作者	ghanemiabdelaziz@hotmail.com
英文摘要	Orexin receptors belong to the big family of G protein coupled receptors (GPCRs) that constitute the main targets in the modern pharmacological approaches. Although the orexinergic system is involved in a variety of processes, treating sleep-wakefulness disorders such as narcolepsy and insomnia, remains the main therapeutic implication of targeting orexinergic receptors. After novel advances, such as the description of the binding pockets, and ligand developments, more researchers are focusing on orexin receptors as promising targets. Furthermore, targeting these receptors may provide therapeutic solutions for some health problems, other than sleep-wakefulness disorders including some psychiatric disorders and neurodegenerative diseases. Within this paper, we put a spotlight on the orexins’ physiology, pathophysiology and pharmacology of mainly sleep-wakefulness. We have also reviewed examples about other orexinergic system-related disorders. We further illustrated recent development in orexin receptors’ agonists and antagonists. In addition, we discussed selected progresses in orexinergic receptors’ ligands.
收录类别	其他
资助信息	This research was supported by the Training Program of the Major Research Plan of the National Natural Science Founda- tion of China (91332120), the National Natural Science Foun- dation of China (31271167, 81271495, 31070963, 30921064) and the Key Program of the Chinese Academy of Sciences (KZCC-EW-103-2).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10965]
专题	昆明动物研究所_神经系统疾病昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 2.University of Chinese Academy of Sciences, Beijing, China 3.Key State Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
推荐引用方式 GB/T 7714	Ghanemi A[*],Hu XT. Targeting the orexinergic system: Mainly but not only for sleep-wakefulness therapies[J]. Alexandria Journal of Medicine,2015,51(X):279–286.
APA	Ghanemi A[*],&Hu XT.(2015).Targeting the orexinergic system: Mainly but not only for sleep-wakefulness therapies.Alexandria Journal of Medicine,51(X),279–286.
MLA	Ghanemi A[*],et al."Targeting the orexinergic system: Mainly but not only for sleep-wakefulness therapies".Alexandria Journal of Medicine 51.X(2015):279–286.