An inhibitor peptide of toll-like receptor 2 shows therapeutic potential for allergic conjunctivitis

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	An inhibitor peptide of toll-like receptor 2 shows therapeutic potential for allergic conjunctivitis
	Xu C 1,2; He XQ 1; Duan ZL 1,2; Lu QM 1,4; Yan XW[]3; Zhang ZY[]1,4; Zheng RQ[*]5; Liu WH 1; Chen Y 3; Zhou CL 3
刊名	International Immunopharmacology
	2017
卷号	46 期号:X 页码:9-15
关键词	Allergy conjunctivitis Immunoregulatory peptide Toll like receptor 2 Staphylococcal enterotoxin B
通讯作者	yanxw@njau.edu.cn ; zhangzhiye5225@163.com ; 13952721411@163.com
英文摘要	Allergic conjunctivitis (AC) is an inflammatory disease of the conjunctiva, which is characterized by antigen challenge and toll-like receptor 2 (TLR2) activation. Here, a designed small peptide ZY12 was found to contain therapeutic potential in staphylococcal enterotoxin B (SEB)-induced AC model. ZY12 treatment showed the remission of clinical signs, plasma total IgE levels, number of mast cells and the proportion of degranulated mast cell in AC mice. Levels of Th2 cytokines (IL-4, IL-5, IL-13) in the lymph nodes or spleen were significantly decreased while those of Th1 cytokine (IFN-γ) were increased in ZY12 treated group, suggesting a protective role of ZY12 in AC by mediating the balance of Th1/Th2 cytokines. Importantly, ZY12 significantly inhibited TLR2 expression in conjunctival tissue. Combined its therapeutic effects with TLR2 inhibitory function, ZY12 might be an ideal candidate for the development of new therapeutic agent for allergic disease.
收录类别	SCI
资助信息	This work was supported by Chinese Academy of Sciences (QYZDJ- SSW-SMC012, SAJC201606, ZSTH-018, West Light Foundation, Youth Innovation Promotion Association CAS (2017432)), National Natural Science Foundation of China (31372208, U1302221, 31200590), and Yunnan Provincial Science and Technology Department (2015BC005, 2016FA006).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10918]
专题	昆明动物研究所_动物毒素室昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Bioactive Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming In- stitute of Zoology, Kunming 650223, Yunnan, China 2.University of Chinese Academy of Sciences, Beijing 100009, China 3.Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China 4.Sino-African Joint Research Center, Chinese Academy of Science, Wuhan, Hubei 430074, China 5.Intensive Care Unit, Subei People's Hospital of Jiangsu Province, Yangzhou, Jiangsu 225001, China
推荐引用方式 GB/T 7714	Xu C,He XQ,Duan ZL,et al. An inhibitor peptide of toll-like receptor 2 shows therapeutic potential for allergic conjunctivitis[J]. International Immunopharmacology,2017,46(X):9-15.
APA	Xu C.,He XQ.,Duan ZL.,Lu QM.,Yan XW[*].,...&Zhou CL.(2017).An inhibitor peptide of toll-like receptor 2 shows therapeutic potential for allergic conjunctivitis.International Immunopharmacology,46(X),9-15.
MLA	Xu C,et al."An inhibitor peptide of toll-like receptor 2 shows therapeutic potential for allergic conjunctivitis".International Immunopharmacology 46.X(2017):9-15.