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	Novel circulating microRNA signature as a potential non-invasive test in LDH patients: a cohort study
	Xiaoya Zhou; Lili Chen; Shishu Huang; Sibylle Grad; Mauro Alini; Songlin Peng
	2015
会议名称	2015国际华人骨研学会ICMRS-美国骨矿研究学会ASBMR大会
会议地点	湖南长沙
英文摘要	Introduction: Lumbar disc herniation (LDH) is one of the major causes for back and sciatic pain that costs large medical expense. Accumulating evidence has indicated that microRNAs (miRNAs), a small non-coding RNA molecule, are associated with disc degeneration, the profile of miRNAs in the LDH patients with indication for laminectomy remains unclear. Material methods: MicroRNA profiling was performed on plasma samples of 4 groups: LDH-young group (n=8, average age is 31), LDH-old group (n=8, average age is 56), healthy control-young group (n=4, average age is 20), healthy control-old group (n=6, average age is 58). The miRNAs expression were further validated by qRT-PCR. Results: The miRNAs with p-values<0.05 and fold change values ≥2 or ≤ 0.5 compared to healthy control were regarded as dysregulated miRNAs. 61 miRNAs were upregulated and 302 were downregulated in LDH-young group compared to healthy control-young group. In addition, there are 46 upregulated miRNAs and 115 downregulated in LDH-old group compared to healthy control-old group. In particular, 12 upregulated and 71 downregulated miRNAs expressed significant differences both in the LDH-young group vs healthy control-young group and the LDH-old group vs healthy control-old group. Among them, miR-224 was upregulated 4.04-, 16.99-fold in LDH-young and LDH-old groups compared to healthy control-young and healthy control-old groups, respectively (p<0.01 for both). Besides, relative to old groups, miR-130b and miR-147b were downregulated significantly in young groups, both of which were reported to be associated with disc degeneration. Conclusion: The selected miRNAs might play a vital role in the molecular pathogenesis of LDH and further research for the understanding of the functionality and pathological mechanism of the miRNAs in LDH is important and would shed new light on LDH.
收录类别	其他
语种	英语
内容类型	会议论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7467]
专题	深圳先进技术研究院_医药所
作者单位	2015
推荐引用方式 GB/T 7714	Xiaoya Zhou,Lili Chen,Shishu Huang,et al. Novel circulating microRNA signature as a potential non-invasive test in LDH patients: a cohort study[C]. 见:2015国际华人骨研学会ICMRS-美国骨矿研究学会ASBMR大会. 湖南长沙.

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