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	Smart Indocyanine Green Nanoprobe for Imaging-Guided Cancer Phototherapy
	Dehong Hu; Haodong Cui; Jingnan Zhang; Zonghai Sheng; Lintao Cai
	2015
会议名称	ChinaNanomedicine 2015
会议地点	Hangzhou, China
英文摘要	Cancer phototherapy has attracted much attention in recent years. To enhance the treatment efficiency of phototherapy and reduce the light-associated side effects, improving drug accumulation and precision guided phototherapy are highly desirable. Herein, we developed a programmed assembly strategy for the preparation of human serum albumin (HSA)-indocyanine green (ICG) nanoparticles (HSA-ICG NPs) by intermolecular disulfide conjugations. Our study indicated that HSA-ICG NPs had a high accumulation with tumor-to-normal tissue ratio of 36.12±5.12 at 24 h and a long-term retention with more than 7 days in xenograft tumors, where the tumor and its margin, normal tissue were be clearly identified via ICG-based in vivo NIR fluorescence imaging and spectrum-resolved technology. Meanwhile, HSA-ICG NPs efficiently induced reactive oxygen species and local hyperthermia simultaneously for synergetic phototherapy. After an intravenous injection of HSA-ICG NPs followed by a single NIR laser dose of 0.8 W/cm2 for 5 min, the tumor was completely suppressed, and no tumor recurrence was observed. Our results suggest programmed assembly of HSA-ICG as a smart theranostic nanoplatform is highly potential for imaging-guided synergetic cancer phototherapy.
收录类别	其他
语种	英语
WOS记录号	WOS:000373923400320
内容类型	会议论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7447]
专题	深圳先进技术研究院_医药所
作者单位	2015
推荐引用方式 GB/T 7714	Dehong Hu,Haodong Cui,Jingnan Zhang,et al. Smart Indocyanine Green Nanoprobe for Imaging-Guided Cancer Phototherapy[C]. 见:ChinaNanomedicine 2015. Hangzhou, China.

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