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	Composite Magnetic Nanocarriers for MRI and Targeted Drug Delivery
	Lijiao Ao; Liang Huang; Wu Su
	2015
会议名称	ChinaNanomedicine 2015
会议地点	Hangzhou, China
英文摘要	The integration of individual superparamagnetic iron oxide nanoparticles (SPIONs) creates the synergistic magnetism, which is desired for enhanced magnetic response and T2 weighted MRI signals.[1] We developed strategies for the assembly of SPIONs and their combination with chemotherapeutic agents, employing novel nanocarriers.[2] The heparin, a biodegradable and natural sourced polysaccharide, was derivated with folic acid (FA) to achieve the amphiphilicity. After micellization of the polymer in water, the FA moieties served as both hydrophobic domains for cargos (SPIONs and doxorubicin) loading, and targeting ligands for cancer cells over-expressing FA receptors. These nanocarriers possessed a desirable size (70 nm), high colloidal stability and sustained doxorubicin release. The high magnetic content in each micelle realized their magnetic field guided targeting to cancer cells, combined with MRI diagnosis and chemotherapy. Another strategy exploited silica nanotubes (SNTs) as novel nanocarriers, for their elongated morphology (favourable for tumor penetration), hollow/porous structure and high chemical affinity to iron oxides. Based on these templates, we fabricated SNT@SPIONs composites by in-situ thermo-decomposition, skipping the conventional pre-synthesis and modification of both SPIONs and the templates. Owning to the synergistic magnetism of the densely loaded SPIONs, the composite nanotubes showed high T2 relaxation rate and quick magnetic response. After doxorubicin loading, the drug carriers were applied for magnetic guided tumor targeting, MRI diagnosis and chemotherapy to cancers.
收录类别	其他
语种	英语
WOS记录号	WOS:000373923400144
内容类型	会议论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7443]
专题	深圳先进技术研究院_医药所
作者单位	2015
推荐引用方式 GB/T 7714	Lijiao Ao,Liang Huang,Wu Su. Composite Magnetic Nanocarriers for MRI and Targeted Drug Delivery[C]. 见:ChinaNanomedicine 2015. Hangzhou, China.

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