Strontium exerts dual effects on calcium phosphate cement: Accelerating the degradation and enhancing the osteoconductivity both in vitro and in vivo

	Strontium exerts dual effects on calcium phosphate cement: Accelerating the degradation and enhancing the osteoconductivity both in vitro and in vivo
	Kuang GuanMing; Yau W. P.; Wu Jun; Yeung Kelvin W. K.; Pan Haobo; Lam W. M.; Lu W. W.; Chiu K. Y.
刊名	JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
	2015
英文摘要	Calcium phosphate cements (CPCs) have long been used as osteoconductive bone substitutes in the treatment of bone defects. However, the degradation rate of CPC is typically too slow to match the new bone growth rate. It is known that strontium increases the solubility of hydroxyapatite as well as exerts both anabolic and anticatabolic effects on bone. Therefore, we hypothesized that the incorporation of strontium would accelerate the degradation rate and enhance the osteoconductivity of CPC. In this study, Three groups, CPC (0% Sr-CPC), 5% Sr-CPC, and 10% Sr-CPC, were prepared, with the total molar ratio for Sr/(Sr+Ca) in the cement powder phase being 0, 5, and 10%, respectively. In the immersion test, less residual weight was observed in both 5% Sr-CPC and 10% Sr-CPC groups than CPC group. In addition, a higher osteoblastic cell proliferation rate and alkaline phosphatase activity were obtained in the strontium groups. In a rat femur bone defect model comparing CPC with 10% Sr-CPC, at 2 weeks postoperation, early endochondral ossification was found in the 10% Sr-CPC group, whereas only fibrous tissue was observed in control group; at 4-16 weeks postoperation, progressive osteoconduction toward the cement was observed in both groups. At 32 weeks, a higher peri-cement bone area and reduced cement area were noted in the 10% Sr-CPC group. In conclusion, in the 10% Sr-CPC group, strontium exerts dual effects on CPC: accelerating degradation rate and enhancing osteoconductivity, as shown here both in vitro and in vivo. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1613-1621, 2015
收录类别	SCI
原文出处	http://www.ncbi.nlm.nih.gov/pubmed/25087971
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7384]
专题	深圳先进技术研究院_医药所
作者单位	JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
推荐引用方式 GB/T 7714	Kuang GuanMing,Yau W. P.,Wu Jun,et al. Strontium exerts dual effects on calcium phosphate cement: Accelerating the degradation and enhancing the osteoconductivity both in vitro and in vivo[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2015.
APA	Kuang GuanMing.,Yau W. P..,Wu Jun.,Yeung Kelvin W. K..,Pan Haobo.,...&Chiu K. Y..(2015).Strontium exerts dual effects on calcium phosphate cement: Accelerating the degradation and enhancing the osteoconductivity both in vitro and in vivo.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A.
MLA	Kuang GuanMing,et al."Strontium exerts dual effects on calcium phosphate cement: Accelerating the degradation and enhancing the osteoconductivity both in vitro and in vivo".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2015).