Efficient Synthesis and Stereochemical Revision of Coibamide A

	Efficient Synthesis and Stereochemical Revision of Coibamide A
	Guiyang Yao; Zhengyin Pan; Chunlei Wu; Wei Wang; Lijing Fang; Wu Su
刊名	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
	2015
英文摘要	Coibamide A is a highly potent antiproliferalive cyclodepsipeptide originally isolated from a Panamanian marine cyanobacterium. Herein we report anefficient solid-phase strategy for assembly of highly N-methylated cyclodepsipeptides, which is invaluable in generating coibamide A derivatives for structure-activity relationship studies. As a consequence of our synthetic studies, two stereochemical assignments of coibamide A were revised and the total synthesis of this natural compound was achieved for the first time.
收录类别	SCI
原文出处	http://pubs.acs.org/doi/abs/10.1021/jacs.5b09286
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7358]
专题	深圳先进技术研究院_医药所
作者单位	JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
推荐引用方式 GB/T 7714	Guiyang Yao,Zhengyin Pan,Chunlei Wu,et al. Efficient Synthesis and Stereochemical Revision of Coibamide A[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2015.
APA	Guiyang Yao,Zhengyin Pan,Chunlei Wu,Wei Wang,Lijing Fang,&Wu Su.(2015).Efficient Synthesis and Stereochemical Revision of Coibamide A.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY.
MLA	Guiyang Yao,et al."Efficient Synthesis and Stereochemical Revision of Coibamide A".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015).