TERRA enhances production of senescence-associated inflammatory cytokines

	TERRA enhances production of senescence-associated inflammatory cytokines
	Pu Wang
刊名	the journal of immunology
	2014
英文摘要	Aged or senescent cells develop a complex senescence-associated secretory phenotype (SASP). However, the mechanisms underlying the induction of the SASP are unclear. Telomeres are critical for genome stability and aging. Telomeres are transcribed into long non-coding telomeric repeat-containing RNA (TERRA) molecules. We demonstrate that TERRA and inflammatory cytokines were significantly elevated during senescence.Over expression of TERRA significantly upregurated IL-6 and IL-8,but IL-6 and IL-8 did not modulate TERRA expression.The results show that TERRA expression is related to senescence and incresse prodution of SASP.Our findings expand biological function of TERRA senescence-associated inflammatory reponses.
收录类别	其他
原文出处	http://www.jimmunol.org/search?fulltext=TERRA+enhances+production+of+senescence-associated+inflammatory+cytokines&submit=yes&x=10&y=7
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/6089]
专题	深圳先进技术研究院_医药所
作者单位	the journal of immunology
推荐引用方式 GB/T 7714	Pu Wang. TERRA enhances production of senescence-associated inflammatory cytokines[J]. the journal of immunology,2014.
APA	Pu Wang.(2014).TERRA enhances production of senescence-associated inflammatory cytokines.the journal of immunology.
MLA	Pu Wang."TERRA enhances production of senescence-associated inflammatory cytokines".the journal of immunology (2014).