Single-step assembly of DOX/ICG loaded lipid–polymer nanoparticles for highly effective chemo-photothermal combination therapy

	Single-step assembly of DOX/ICG loaded lipid–polymer nanoparticles for highly effective chemo-photothermal combination therapy
	Zheng, Mingbin; Yue, Caixia; Ma, Yifan; Gong, Ping; Zhao, Pengfei; Zheng, Cuifang; Sheng, Zonghai; Zhang, Pengfei; Wang, Zhaohui; Cai, Lintao
刊名	ACS NANO
	2013
英文摘要	A combination of chemotherapy and photothermal therapy has emerged as a promising strategy for cancer therapy. To ensure the chemotherapeutic drug andphotothermal agent could be simultaneously delivered to a tumor region to exert their synergistic effect, a safe and efficient delivery system is highly desirable. Herein, we fabricated doxorubicin (DOX) and indocyanine green (ICG) loaded poly(lactic-co-glycolic acid) (PLGA) lecithin polyethylene glycol (PEG)nanoparticles (DINPs) using a single-step sonication method. The DINPs exhibited good monodispersity, excellent fluorescence/size stability, and consistent spectra characteristics compared with free ICG or DOX. Moreover, the DINPs showed higher temperature response, faster DOX release under laser irradiation, and longer retention time in tumor. In the meantime, the fluorescence of DOX and ICG in DINPs was also visualized for the process of subcellular location in vitro and metabolic distribution in vivo. In comparison with chemo or photothermal treatment alone, the combined treatment of DINPs with laser irradiation synergistically induced the apoptosis and death of DOX-sensitive MCF-7 and DOX-resistant MCF-7/ADR cells, and suppressed MCF-7 and MCF-7/ADR tumor growth in vivo. Notably, no tumor recurrence was observed after only a single dose of DINPs with laser irradiation. Hence, the well-defined DINPs exhibited great potential in targeting cancer imaging and chemo-photothermal therapy.
收录类别	SCI
原文出处	http://pubs.acs.org/doi/abs/10.1021/nn400334y
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/5190]
专题	深圳先进技术研究院_医药所
作者单位	ACS NANO
推荐引用方式 GB/T 7714	Zheng, Mingbin,Yue, Caixia,Ma, Yifan,et al. Single-step assembly of DOX/ICG loaded lipid–polymer nanoparticles for highly effective chemo-photothermal combination therapy[J]. ACS NANO,2013.
APA	Zheng, Mingbin.,Yue, Caixia.,Ma, Yifan.,Gong, Ping.,Zhao, Pengfei.,...&Cai, Lintao.(2013).Single-step assembly of DOX/ICG loaded lipid–polymer nanoparticles for highly effective chemo-photothermal combination therapy.ACS NANO.
MLA	Zheng, Mingbin,et al."Single-step assembly of DOX/ICG loaded lipid–polymer nanoparticles for highly effective chemo-photothermal combination therapy".ACS NANO (2013).