Effect of Low-Dose X-Ray Irradiation and Ti Particles on the Osseointegration of Prosthetic

	Effect of Low-Dose X-Ray Irradiation and Ti Particles on the Osseointegration of Prosthetic
	Chang She; Gao-Long Shi; Wei Xu; Xiao-Zhong Zhou; Jian Li; Ye Tian; Jian Li; Wei-Hao Li; Qi-Rong Dong; Pei-Gen Ren
刊名	Journal of Orthopaedic Research
	2016
英文摘要	Low-dose irradiation (LDI) exhibits a positive effect on osteoblasts and inhibitory effect of inflammation. Here, we test the hypothesis that LDI can promote osseointegration and inhibit the inflammatory membrane formation in the presence of titanium (Ti) particles. Endotoxin-free titanium particles were injected into rabbit, prior to the insertion of a Ti6-Al-4-V sticks pre-coated with hydroxyapatite. Two days after operation, both distal femurs of the animal were exposed to 0.5Gy X-ray irradiation. All animals were euthanized 8 weeks after the operation. The PINP concentration was determined at day 0, 2, 4, and 8 weeks after operation. Trabecular morphology around the implants 8 weeks after operation was assessed using micro-CT, then the maximum push out force of simples was assessed using biomechanics test. Five samples in each group were chosen for bone histomorphology study without decalcification 8 weeks after operation. The results confirmed that the LDI can significantly improve ingrowth of bone into the prosthetic interface and stability of the prosthesis when there was no wear particles. Although promotion effects for bone formation induced by LDI can be counteracted by wear particles, LDI can significantly inhibit the interface membrane formation around the implant induced by wear particles. Based on these results, we conclude that LDI may be useful for enhancing the stability of prosthesis when there are no wear particles and for inhibiting the interface membrane formation during the early stage of aseptic loosening in the presence of wear particles. 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res
收录类别	SCI
原文出处	http://www.ncbi.nlm.nih.gov/pubmed/?term=Effect+of+Low-Dose+X-Ray+Irradiation+and+Ti+Particles+on+the+Osseointegration+of+Prosthetic
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10513]
专题	深圳先进技术研究院_医工所
作者单位	Journal of Orthopaedic Research
推荐引用方式 GB/T 7714	Chang She,Gao-Long Shi,Wei Xu,et al. Effect of Low-Dose X-Ray Irradiation and Ti Particles on the Osseointegration of Prosthetic[J]. Journal of Orthopaedic Research,2016.
APA	Chang She.,Gao-Long Shi.,Wei Xu.,Xiao-Zhong Zhou.,Jian Li.,...&Pei-Gen Ren.(2016).Effect of Low-Dose X-Ray Irradiation and Ti Particles on the Osseointegration of Prosthetic.Journal of Orthopaedic Research.
MLA	Chang She,et al."Effect of Low-Dose X-Ray Irradiation and Ti Particles on the Osseointegration of Prosthetic".Journal of Orthopaedic Research (2016).