The development of the intrinsic functional connectivity of default network subsystems from age 3 to 5

	The development of the intrinsic functional connectivity of default network subsystems from age 3 to 5
	Yaqiong Xiao; Hongchang Zhai; Angela D.Friederici; Fucang Jia
刊名	Brain Imaging and Behavior
	2016
英文摘要	In recent years, research on human functional brain imaging using resting-state fMRI techniques has been increasingly prevalent. The term Bdefault mode^ was proposed to describe a baseline or default state of the brain during rest. Recent studies suggested that the default mode network (DMN) is comprised of two functionally distinct subsystems: a dorsal-medial prefrontal cortex (DMPFC) subsystem involved in self-oriented cognition (i.e., theory of mind) and a medial temporal lobe (MTL) subsystem engaged in memory and scene construction; both subsystems interact with the anterior medial prefrontal cortex (aMPFC) and posterior cingulate (PCC) as the core regions of DMN. The present study explored the development of DMN core regions and these two subsystems in both hemispheres from 3- to 5-year-old children. The analysis of the intrinsic activity showed strong developmental changes in both subsystems, and significant changes were specifically found in MTL subsystem, but not mental activities. These results also indicate that there is stronger right hemispheric lateralization at age 3, which then changes as bilateral development gradually increases through to age 5, suggesting in turn the hemispheric dominance in DMN subsystems changing with age. The present results provide primary evidence for the development of DMN subsystems in early life, which might be closely related to the development of social cognition in childhood. in DMPFC subsystem, implying distinct developmental trajectories for DMN subsystems.We found stronger interactions between the DMPFC and MTL subsystems in 5-year-olds, particularly in the left subsystems that support the development of environmental adaptation and relatively complex
收录类别	SCI
原文出处	http://link.springer.com/article/10.1007/s11682-015-9362-z
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/10381]
专题	深圳先进技术研究院_医工所
作者单位	Brain Imaging and Behavior
推荐引用方式 GB/T 7714	Yaqiong Xiao,Hongchang Zhai,Angela D.Friederici,et al. The development of the intrinsic functional connectivity of default network subsystems from age 3 to 5[J]. Brain Imaging and Behavior,2016.
APA	Yaqiong Xiao,Hongchang Zhai,Angela D.Friederici,&Fucang Jia.(2016).The development of the intrinsic functional connectivity of default network subsystems from age 3 to 5.Brain Imaging and Behavior.
MLA	Yaqiong Xiao,et al."The development of the intrinsic functional connectivity of default network subsystems from age 3 to 5".Brain Imaging and Behavior (2016).