Lubricin in Human Achilles Tendon: the Evidence of Intratendinous Sliding Motion and Shear Force in Achilles Tendon

	Lubricin in Human Achilles Tendon: the Evidence of Intratendinous Sliding Motion and Shear Force in Achilles Tendon
	Yu-Long Sun; Zhuang Wei; Chunfeng Zhao; Gregory D. Jay; M.D.Thomas M. Schmid; Peter C. Amadio; Kai-Nan An
刊名	J Orthop Res
	2015
英文摘要	Achilles tendon is one of the most commonly injured tendons. Mechanical force is regarded as a major causative factor. However, the biomechanics of Achilles tendon and mechanical mechanism of the injuries are unclear. Lubricin expresses at regions exposed to sliding motion and shear force in a number of tissues. This study investigated the distribution and concentration of lubricin in human Achilles tendons for better understanding the biomechanics of Achilles tendon. Achilles tendons were harvested from nine cadavers. Lubricin was extracted from various locations proximal to the calcaneal insertion and quantified with ELISA. The distribution of lubricin was investigated with immunohistochemistry. Lubricin was mainly identified at the interfaces of tendon fascicles, especially in the mid-portion of the tendon. The concentration of lubricin in Achilles tendons varied by individual and the distance from its calcaneal insertion. The distal portion of the tendon had a higher concentration of lubricin than the proximal regions of the tendon. This study suggests the presence of intratendinous sliding motion of fascicles and shear force at interfaces of fascicles in human Achilles tendon. Shear force could be an important mechanical factor for the development of Achilles tendinopathy and rupture. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:932-937, 2015.
收录类别	SCI
原文出处	http://onlinelibrary.wiley.com/doi/10.1002/jor.22897/abstract
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7177]
专题	深圳先进技术研究院_医工所
作者单位	J Orthop Res
推荐引用方式 GB/T 7714	Yu-Long Sun,Zhuang Wei,Chunfeng Zhao,et al. Lubricin in Human Achilles Tendon: the Evidence of Intratendinous Sliding Motion and Shear Force in Achilles Tendon[J]. J Orthop Res,2015.
APA	Yu-Long Sun.,Zhuang Wei.,Chunfeng Zhao.,Gregory D. Jay.,M.D.Thomas M. Schmid.,...&Kai-Nan An.(2015).Lubricin in Human Achilles Tendon: the Evidence of Intratendinous Sliding Motion and Shear Force in Achilles Tendon.J Orthop Res.
MLA	Yu-Long Sun,et al."Lubricin in Human Achilles Tendon: the Evidence of Intratendinous Sliding Motion and Shear Force in Achilles Tendon".J Orthop Res (2015).