Resveratrol Triggers Protective Autophagy Through the Ceramide/Akt/mTOR Pathway in Melanoma B16 Cells

	Resveratrol Triggers Protective Autophagy Through the Ceramide/Akt/mTOR Pathway in Melanoma B16 Cells
	Wang Meng; Yu Teng; Zhu Chengyao; Sun Hui; Qiu Ying; Zhu Xia; Li Jinchao
刊名	NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
	2014
英文摘要	Resveratrol (3,5,4′-trihydroxy-trans-stilbene, RSV), a natural polyphenolic compound, is known as a promising anti-cancer agent. In this study, we showed that RSV could inhibit the growth of B16 cells via induction of apoptosis. Moreover, our results showed for the first time that RSV induced autophagy in B16 cells, which might occur through ceramide accumulation and Akt/mTOR pathway inhibition. Inhibition of autophagy by an autophagic inhibitor 3-methyladenine (3-MA) or si-Beclin 1 enhanced RSV-induced cytotoxicity and apoptosis. Thus, autophagy inhibition represents a promising approach to improve the efficacy of RSV in the treatment of patients with melanoma.
收录类别	SCI
原文出处	http://www.tandfonline.com/doi/abs/10.1080/01635581.2013.878738#.VccvAtKl_bM
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/5861]
专题	深圳先进技术研究院_医工所
作者单位	NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
推荐引用方式 GB/T 7714	Wang Meng,Yu Teng,Zhu Chengyao,et al. Resveratrol Triggers Protective Autophagy Through the Ceramide/Akt/mTOR Pathway in Melanoma B16 Cells[J]. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL,2014.
APA	Wang Meng.,Yu Teng.,Zhu Chengyao.,Sun Hui.,Qiu Ying.,...&Li Jinchao.(2014).Resveratrol Triggers Protective Autophagy Through the Ceramide/Akt/mTOR Pathway in Melanoma B16 Cells.NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL.
MLA	Wang Meng,et al."Resveratrol Triggers Protective Autophagy Through the Ceramide/Akt/mTOR Pathway in Melanoma B16 Cells".NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2014).