Rapid isolation of cancer cells using microfluidic deterministic lateral displacement structure

	Rapid isolation of cancer cells using microfluidic deterministic lateral displacement structure
	Zongbin Liu; Fei Huang; Jinghui Du; Weiliang Shu; Hongtao Feng; Xiaoping Xu; Yan Chen
刊名	BIOMICROFLUIDICS
	2013
英文摘要	This work reports a microfluidic device with deterministic lateral displacement (DLD) arrays allowing rapid and label-free cancer cell separation and enrichment from diluted peripheral whole blood, by exploiting the size-dependent hydrodynamic forces. Experiment data and theoretical simulation are presented to evaluate the isolation efficiency of various types of cancer cells in the microfluidic DLD structure. We also demonstrated the use of both circular and triangular post arrays for cancer cell separation in cell solution and blood samples. The device was able to achieve high cancer cell isolation efficiency and enrichment factor with our optimized design. Therefore, this platform with DLD structure shows great potential on fundamental and clinical studies of circulating tumor cells.
收录类别	SCI
原文出处	http://scitation.aip.org/content/aip/journal/bmf/7/1/10.1063/1.4774308
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/4806]
专题	深圳先进技术研究院_医工所
作者单位	BIOMICROFLUIDICS
推荐引用方式 GB/T 7714	Zongbin Liu,Fei Huang,Jinghui Du,et al. Rapid isolation of cancer cells using microfluidic deterministic lateral displacement structure[J]. BIOMICROFLUIDICS,2013.
APA	Zongbin Liu.,Fei Huang.,Jinghui Du.,Weiliang Shu.,Hongtao Feng.,...&Yan Chen.(2013).Rapid isolation of cancer cells using microfluidic deterministic lateral displacement structure.BIOMICROFLUIDICS.
MLA	Zongbin Liu,et al."Rapid isolation of cancer cells using microfluidic deterministic lateral displacement structure".BIOMICROFLUIDICS (2013).