Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice

	Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice
	Hui-Juan Cao; Rui-Rong Tan; Rong-Rong He; Lu-Ping Tang; Xin-Luan Wang; Nan Yao; Wen-Jun Duan; Yuan-Ao Hu; Xin-Sheng Yao; Hiroshi Kurihara
刊名	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
	2012
英文摘要	Sarcandra glabra, as a type of “antipyretic-detoxicate drugs”, has always been widely used in traditional Chinese medicine (TCM). The Sarcandra glabra extract (SGE) is applied frequently as anti-inflammatory and anti-infectious drug in folk medicine. However, relative experiment data supporting this effective clinical consequence was limited. In order to mimic the physiological conditions of the susceptible population, we employed restraint stress mouse model to investigate the effect of SGE against influenza. Mice were infected with influenza virus three days after restraint, while SGE was orally administrated for 10 consecutive days. Body weight, morbidity, and mortality were recorded daily. Histopathologic changes, susceptibility genes expressions and inflammatory markers in lungs were determined. Our results showed that restraint stress significantly increased susceptibility and severity of influenza virus. However, oral administration of SGE could reduce morbidity, mortality and significantly prolonged survival time. The results further showed that SGE had a crucial effect on improving susceptibility markers levels to recover the balance of host defense system and inhibiting inflammatory cytokines levels through down-regulation of NF-B protein expression to ameliorate the lung injury. These data showed that SGE reduced the susceptibility and severity of influenza.
收录类别	SCI
原文出处	http://www.hindawi.com/journals/ecam/2012/236539/
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/4036]
专题	深圳先进技术研究院_医工所
作者单位	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
推荐引用方式 GB/T 7714	Hui-Juan Cao,Rui-Rong Tan,Rong-Rong He,et al. Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2012.
APA	Hui-Juan Cao.,Rui-Rong Tan.,Rong-Rong He.,Lu-Ping Tang.,Xin-Luan Wang.,...&Hiroshi Kurihara.(2012).Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA	Hui-Juan Cao,et al."Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2012).