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	Photoacoustic/ultrasonic dual-modality endoscopy in vivo
	Riqiang Lin; Yan Li; Jianhua Chen; Liang Song
	2015
会议名称	International Conference on Nanomedicine and NanoBiotechnology
会议地点	海口
英文摘要	Abstract—Early diagnosis and treatment of cancer are of vital importance. Novel imaging methods are in great need to achieve this. Photoacoustic endoscopy (PAE) is an emerging endoscopic technology capable of providing both functional and molecular information of intact biological tissue of internal organs in vivo. With endogenous or exogenous contrast agent, cancer formation and the corresponding vascular morphology and function changes can be detected and imaged by PAE. In addition, Utilizing multi-wavelength laser excitation, a number of important physiological parameters, such as the total hemoglobin concentration, oxygen saturation of hemoglobin, and micro-hemodynamic flux, can be obtained by PAE. Such information directly correlates with vascular angiogenesis and abnormal metabolisms and thus reflects the formation and progression of many neoplasms. In our study, a miniaturized, simple and full field-of-view photoacoustic/ultrasonic endoscopy system was developed. A flexible coil was used to transmit the rotational torque from the rotary stage, which enables a 360o field-of-view imaging in vivo, for the first time to our knowledge. The developed imaging catheter was fully encapsulated by a single-use protective polyamide tube. A B-scan rate up to 5 Hz (200 A-lines/B-scan) was achieved. Three-dimentional photoacoustic and ultrasound images of the rectum from a SD rat were acquired in vivo. The significantly improved imaging field-of-view, together with the flexible, simple and encapsulated catheter design, suggests that this PAE system can be of great interest for clinical translation for a variety of endoscopic applications, such as the urogenital, colorectal and gastrointestinal tract imaging.
收录类别	其他
语种	英语
内容类型	会议论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/7219]
专题	深圳先进技术研究院_医工所
作者单位	2015
推荐引用方式 GB/T 7714	Riqiang Lin,Yan Li,Jianhua Chen,et al. Photoacoustic/ultrasonic dual-modality endoscopy in vivo[C]. 见:International Conference on Nanomedicine and NanoBiotechnology. 海口.

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