Dynamic Cerebral Autoregulation in Asymptomatic Patients With Unilateral Middle Cerebral Artery Stenosis

	Dynamic Cerebral Autoregulation in Asymptomatic Patients With Unilateral Middle Cerebral Artery Stenosis
	Shuang Wang; Zhen-Ni Guo; Yingqi Xing; Hongyin Ma; Hang Jin; Jia Liu; Yi Yang
刊名	Medicine
	2015
英文摘要	Abstract: The aim of the study was to assess the capacity of dynamic cerebral autoregulation (dCA) in asymptomatic patients with unilateral middle cerebral artery (MCA) stenosis. Fifty-seven patients with asymptomatic mild, moderate, and severe unilateral MCA stenosis and 8 patients with symptomatic severe unilateral MCA stenosis diagnosed by transcranial Doppler were enrolled. Twenty-four healthy volunteers served as controls. The non- invasive continuous cerebral blood flow velocity and arterial blood pressure were recorded simultaneously from each subject in the supine position. Transfer function analysis was applied to determine the auto- regulatory parameters (phase difference [PD] and gain). The PDvaluesin the severe stenosis groupswere significantlylower than those of the control group (60.71?18.638), the asymptomatic severe stenosis group was impaired ipsilaterally (28.94?27.438, P<0.001), and the symptomatic severe stenosis group was impaired bilaterally (13.74?19.218, P<0.001; 19.68?14.508, P¼0.006, respectively). The PD values in the mild and moderate stenosis groups were not significantly different than the controls (44.49?27.938; 48.65?25.498, respectively). The gain values in the mild and moderate groups were higher than in the controls (1.00?0.58cm/s/mm Hg vs 0.86?0.34cm/s/mm Hg, and 1.20?0.59cm/s/mm Hg vs 0.86?0.34cm/s/mm Hg, respectively). The gain values in the severe stenosis groups were significantly lower than that in the control group: the asymptomatic severe stenosis group was lower bilaterally (0.56?0.32cm/s/mm Hg, P¼0.003; 0.60?0.32cm/s/mm Hg, P<0.05, respectively), whereas the symptomatic severe group was lower unilaterally (on the contralateral side) (0.53?0.43cm/s/mm Hg, P<0.05).In asymptomatic patients with unilateral MCA stenosis, only the dCA of the severe stenosis was ipsilaterally impaired. Acute stroke may aggravate the impaired dCA and even spread contralaterally.
收录类别	SCI
原文出处	http://journals.lww.com/md-journal/pages/default.aspx
语种	英语
WOS记录号	WOS:000369856700012
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/6915]
专题	深圳先进技术研究院_数字所
作者单位	Medicine
推荐引用方式 GB/T 7714	Shuang Wang,Zhen-Ni Guo,Yingqi Xing,et al. Dynamic Cerebral Autoregulation in Asymptomatic Patients With Unilateral Middle Cerebral Artery Stenosis[J]. Medicine,2015.
APA	Shuang Wang.,Zhen-Ni Guo.,Yingqi Xing.,Hongyin Ma.,Hang Jin.,...&Yi Yang.(2015).Dynamic Cerebral Autoregulation in Asymptomatic Patients With Unilateral Middle Cerebral Artery Stenosis.Medicine.
MLA	Shuang Wang,et al."Dynamic Cerebral Autoregulation in Asymptomatic Patients With Unilateral Middle Cerebral Artery Stenosis".Medicine (2015).