Characterization of an H3N2 canine influenza virus isolated from Tibetan mastiffs in China

	Characterization of an H3N2 canine influenza virus isolated from Tibetan mastiffs in China
	Teng Qiaoyang; Zhang Xu; Xu Dawei; Zhou Jiewen; Dai Xiaoguang; Chen Zhaoguo; Li Zejun
刊名	VETERINARY MICROBIOLOGY
	2013
英文摘要	Ten 3-month-old Tibetan mastiffs became ill 2 days after they were bought from a Tibetan mastiff exhibition, and 4 of them died 2 weeks later. A canine influenza virus (ZJ0110) was isolated from the lung of a deceased Tibetan mastiff and was characterized in detail. Sequence analysis indicated that the 8 genes of the canine isolate were most similar to those of avian-origin canine influenza viruses (H3N2) isolated in South Korea in 2007, with which they shared >98% sequence identity. ZJ0110 could experimentally infect 6-month-old beagles by intranasal inoculation and by airborne transmission, causing severe respiratory syndrome. Moreover, ZJ0110 could replicate in the upper respiratory tracts of mice and guinea pigs, and the virus titer was comparable to that in the upper respiratory tracts of dogs. Although the virus was genetically of avian origin, ZJ0110 could not experimentally infect chicken or ducks by intranasal inoculation. These results suggest that dogs might be an intermediary host in which avian influenza viruses adapt to replicate in mammals.
收录类别	SCI
原文出处	http://www.sciencedirect.com/science/article/pii/S0378113512005457#
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/5237]
专题	深圳先进技术研究院_其他
作者单位	VETERINARY MICROBIOLOGY
推荐引用方式 GB/T 7714	Teng Qiaoyang,Zhang Xu,Xu Dawei,et al. Characterization of an H3N2 canine influenza virus isolated from Tibetan mastiffs in China[J]. VETERINARY MICROBIOLOGY,2013.
APA	Teng Qiaoyang.,Zhang Xu.,Xu Dawei.,Zhou Jiewen.,Dai Xiaoguang.,...&Li Zejun.(2013).Characterization of an H3N2 canine influenza virus isolated from Tibetan mastiffs in China.VETERINARY MICROBIOLOGY.
MLA	Teng Qiaoyang,et al."Characterization of an H3N2 canine influenza virus isolated from Tibetan mastiffs in China".VETERINARY MICROBIOLOGY (2013).