Aberrant promoter CpG methylation and its translational applications in breast cancer

	Aberrant promoter CpG methylation and its translational applications in breast cancer
	Xiang Ting-Xiu; Yuan Ying; Li Li-Li; Wang Zhao-Hui; Dan Liang-Ying; Chen Yan; Ren Guo-Sheng; Tao Qian
刊名	CHINESE JOURNAL OF CANCER
	2013
英文摘要	Breast cancer is a complex disease driven by multiple factors including both genetic and epigenetic alterations. Recent studies revealed that abnormal gene expression induced by epigenetic changes, including aberrant promoter methylation and histone modification, plays a critical role in human breast carcinogenesis. Silencing of tumor suppressor genes (TSGs) by promoter CpG methylation facilitates cells growth and survival advantages and further results in tumor initiation and progression, thus directly contributing to breast tumorigenesis. Usually, aberrant promoter methylation of TSGs, which can be reversed by pharmacological reagents, occurs at the early stage of tumorigenesis and therefore may serve as a potential tumor marker for early diagnosis and therapeutic targeting of breast cancer. In this review, we summarize the epigenetic changes of multiple TSGs involved in breast pathogenesis and their potential clinical applications as tumor markers for early detection and treatment of breast cancer.
收录类别	SCI
原文出处	http://www.cjcsysu.cn/abstract.asp?fr=doi&idno=18061
语种	英语
内容类型	期刊论文
源URL	[http://ir.siat.ac.cn:8080/handle/172644/5232]
专题	深圳先进技术研究院_其他
作者单位	CHINESE JOURNAL OF CANCER
推荐引用方式 GB/T 7714	Xiang Ting-Xiu,Yuan Ying,Li Li-Li,et al. Aberrant promoter CpG methylation and its translational applications in breast cancer[J]. CHINESE JOURNAL OF CANCER,2013.
APA	Xiang Ting-Xiu.,Yuan Ying.,Li Li-Li.,Wang Zhao-Hui.,Dan Liang-Ying.,...&Tao Qian.(2013).Aberrant promoter CpG methylation and its translational applications in breast cancer.CHINESE JOURNAL OF CANCER.
MLA	Xiang Ting-Xiu,et al."Aberrant promoter CpG methylation and its translational applications in breast cancer".CHINESE JOURNAL OF CANCER (2013).