Sensitive imaging and effective capture of Cu2+: Towards highly efficient theranostics of Alzheimer's disease | |
Cui, Zhaowen1,2; Bu, Wenbo1,3; Fan, Wenpei1; Zhang, Jiawen4; Ni, Dalong1; Liu, Yanyan1; Wang, Jing4; Liu, Jianan1; Yao, Zhenwei4; Shi, Jianlin1,2 | |
刊名 | BIOMATERIALS |
2016-10-01 | |
卷号 | 104页码:158-167 |
关键词 | Upconversion nanoparticles Alzheimer's disease Nanotheranostics Sensing LRET |
英文摘要 | As a distinct feature of Alzheimer's disease (AD), the presence of excess metal ions in the brain is most probably one of the main causative factors for the aggregation of beta-Amyloid (A beta) proteins. The design of nanoprobes for detection and control of ion concentrations will be of great importance in predicting the progression of AD and simultaneously providing effective treatments. Herein, we report the design and synthesis of a novel yet smart nanoprobe that can sensitively detect the Cu2+ concentration and concurrently capture Cu2+ both in vitro and in vivo. The designed nanoprobe (UCHQ) combines two main components: upconversion nanoparticles (UCNPs) used for the detection and upconversion luminescence (UCL) imaging of Cu2+ upon 980 nm exposure and the chelator 8-hydroxyquinoline-2-carboxylic acid (HQC) used for chelating Cu2+ and AD therapy. The results show that the emission intensity of UCHQ is highly dependent on the Cu2+ concentrations due to the luminescence resonance energy transfer (LRET) from UCNPs to HQC-bonded Cu2+. Fascinatingly, the as-constructed UCHQs could be used for UCL imaging of A beta both in cells and AD mice. Most importantly, UCHQs could not only inhibit the A beta aggregation-induced apoptosis via capturing overmuch Cu2+ but also accelerate the nontoxic structural transformation of A beta. (C) 2016 Elsevier Ltd. All rights reserved. |
WOS标题词 | Science & Technology ; Technology |
类目[WOS] | Engineering, Biomedical ; Materials Science, Biomaterials |
研究领域[WOS] | Engineering ; Materials Science |
关键词[WOS] | IN-VIVO DETECTION ; AMYLOID-BETA ; A-BETA ; TRANSGENIC MICE ; NANOPARTICLES ; BRAIN ; IONS ; AGGREGATION ; HYPOTHESIS ; COGNITION |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000382345000014 |
内容类型 | 期刊论文 |
源URL | [http://ir.sic.ac.cn/handle/331005/22108] |
专题 | 上海硅酸盐研究所_高性能陶瓷和超微结构国家重点实验室_期刊论文 |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Shanghai Tech Univ, Shanghai 201210, Peoples R China 3.East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China 4.Fudan Univ, Huashan Hosp, Dept Radiol, Shanghai 200040, Peoples R China |
推荐引用方式 GB/T 7714 | Cui, Zhaowen,Bu, Wenbo,Fan, Wenpei,et al. Sensitive imaging and effective capture of Cu2+: Towards highly efficient theranostics of Alzheimer's disease[J]. BIOMATERIALS,2016,104:158-167. |
APA | Cui, Zhaowen.,Bu, Wenbo.,Fan, Wenpei.,Zhang, Jiawen.,Ni, Dalong.,...&Shi, Jianlin.(2016).Sensitive imaging and effective capture of Cu2+: Towards highly efficient theranostics of Alzheimer's disease.BIOMATERIALS,104,158-167. |
MLA | Cui, Zhaowen,et al."Sensitive imaging and effective capture of Cu2+: Towards highly efficient theranostics of Alzheimer's disease".BIOMATERIALS 104(2016):158-167. |
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