Acute metabolic response of Portunus trituberculatus to Vibrio alginolyticus infection

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振基础研究部

	Acute metabolic response of Portunus trituberculatus to Vibrio alginolyticus infection
	Ye, Yangfang 1,2; Xia, Mengjie 1; Mu, Changkao 1; Li, Ronghua 1; Wang, Chunlin 1
刊名	AQUACULTURE
	2016-10-01
卷号	463 页码:201-208
关键词	Portunus trituberculatus Vibrio alginolyticus Metabolomics Nuclear magnetic resonance Multivariate data analysis
英文摘要	Vibrio alginolyticus is a common pathogen that causes vibrio disease in swimming crab, Portunus trituberculatus. An understanding of the metabolic responsemechanism of swimming crab to V. alginolyticus is essential for further control of this disease. In the present study, we analyzed the metabolic responses of gill, hepatopancreas, and muscle of swimming crab to an acute V. alginolyticus infection using H-1 NMR spectroscopy coupled with multivariate data analysis. Our results showed that V. alginolyticus infection induced significant metabolomic alterations in crab muscle and gill within 24 h. These alterations showed tissue-specific in the infected swimming crabs. V. alginolyticus infection resulted in depression of gluconeogenesis from amino acids, improvement of energy accumulation, and enhancement of cellular immune response of muscle. These metabolic alterations were highlighted in the depletion of amino acids and inosine monophosphate as well as in the accumulation of ATP and betaine in muscle. Vibrio infection also caused energy disturbance in gill, which manifested in the depletion of glucose and in the accumulation of lactate and adenosine monophosphate. These findings provided details of acute metabolomic alterations of swimming crab after V. alginolyticus infection and demonstrated the potentiality of altered metabolites as biomarker in vibrio infection.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Fisheries ; Marine & Freshwater Biology
研究领域[WOS]	Fisheries ; Marine & Freshwater Biology
关键词[WOS]	ANTILIPOPOLYSACCHARIDE FACTOR ; INOSINE MONOPHOSPHATE ; MOLECULAR-CLONING ; IMMUNE-RESPONSE ; EXPRESSION ; RESISTANCE ; STRESS ; METABONOMICS ; HOMEOSTASIS ; CHALLENGE
收录类别	SCI
语种	英语
WOS记录号	WOS:000381010800027
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/9617]
专题	武汉物理与数学研究所_磁共振基础研究部
作者单位	1.Ningbo Univ, Minist Educ, Key Lab Appl Marine Biotechnol, 818 Fenghua Rd, Ningbo 315211, Zhejiang, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Ye, Yangfang,Xia, Mengjie,Mu, Changkao,et al. Acute metabolic response of Portunus trituberculatus to Vibrio alginolyticus infection[J]. AQUACULTURE,2016,463:201-208.
APA	Ye, Yangfang,Xia, Mengjie,Mu, Changkao,Li, Ronghua,&Wang, Chunlin.(2016).Acute metabolic response of Portunus trituberculatus to Vibrio alginolyticus infection.AQUACULTURE,463,201-208.
MLA	Ye, Yangfang,et al."Acute metabolic response of Portunus trituberculatus to Vibrio alginolyticus infection".AQUACULTURE 463(2016):201-208.