Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 肿瘤生物学

	Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer
	Kong YJ 1,3; Chen JC 2; Zhou ZM 1; Xia HJ 1; Qiu MH[]2; Chen CS[]1
刊名	PLOS ONE
	2014
卷号	9 期号:7 页码:e103760
通讯作者	qiuminghua@mail.kib.ac.cn ; chenc@mail.kiz.ac.cn
英文摘要	Triple negative breast cancer (TNBC) is a highly aggressive form of breast cancer resistant to many common treatments. In this study, we compared the effects of 12 phytochemical drugs on four cancer cell lines, and noticed that Cucurbitacin E (CuE) significantly inhibited TNBC cell growth by inducing cell cycle G2/M phase arrest and apoptosis. CuE reduced expression of Cyclin D1, Survivin, XIAP, Bcl2, and Mcl-1 in MDA-MB-468 and SW527, and within MDA-MB-468, CuE significantly increased activation of JNK and inhibited activation of AKT and ERK. Collectively, these results suggest that CuE may be a viable compound for developing novel TNBC therapeutics.
资助信息	This work was supported by National Natural Science Foundation of China (81120108019, U1132605, and 81325016 to Chen, C; U1192604 and 39970086 to Qiu, M).
语种	英语
WOS记录号	WOS:000341307600085
公开日期	2014-10-10
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8028]
专题	昆明动物研究所_肿瘤生物学昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming, Yunnan, China 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China
推荐引用方式 GB/T 7714	Kong YJ,Chen JC,Zhou ZM,et al. Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer[J]. PLOS ONE,2014,9(7):e103760.
APA	Kong YJ,Chen JC,Zhou ZM,Xia HJ,Qiu MH[],&Chen CS[].(2014).Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer.PLOS ONE,9(7),e103760.
MLA	Kong YJ,et al."Cucurbitacin E Induces Cell Cycle G2/M Phase Arrest and Apoptosis in Triple Negative Breast Cancer".PLOS ONE 9.7(2014):e103760.