Exposure to chronic constant light impairs spatial memory and influences long-term depression in rats

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 学习记忆的分子神经机制

	Exposure to chronic constant light impairs spatial memory and influences long-term depression in rats
	Ma WP 1,2,5; Cao J 2; Yang YX[]2; Xu L[]1,2,4; Tian M 2; Cui MH 4; Han HL 2,3
刊名	NEUROSCIENCE RESEARCH
	2007
卷号	59 期号:2 页码:224-230
关键词	constant light stress circadian rhythm adaptation synaptic plasticity Morris water maze
通讯作者	lxu@vip.163.com ; Yangyx0553@yahoo.com.cn
英文摘要	Exposure to chronic constant light (CCL) influences circadian rhythms and evokes stress. Since hippocampus is sensitive to stress, which facilitates long-term depression (LTD) in the hippocampal CA1 area, we examined whether CCL exposure influenced hippocampus-dependent spatial memory and synaptic plasticity in Wistar rats. Here we report that CCL exposure (3 weeks) disrupted 24-h cycle of locomotion activity in open field test. These rats showed shorter escape latency during initial phase of spatial leaming but impaired hippocampus-dependent spatial memory without affecting the visual platform learning task in Morris water maze (MWM) compared with control rats. This effect may be due to stress adaptation as reflected by reduced thigmotaxis and anxiety-like behaviors in CCL rats. Moreover, in CA1 area of the hippocampal slices, CCL rats failed to show LTD by low frequency stimulation (LFS, 900 pulses, 1 Hz), while showed decreased short-term depression compared with control rats indicating the induction of LTD was influenced by CCL exposure. Furthermore, additional acute stress enabled LFS to induce LTD in control rats but not in CCL rats. Thus, these results suggested that CCL exposure impaired spatial memory and influenced hippocampal LTD, which may be due to stress adaptation. (C) 2007 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
收录类别	SCI
资助信息	This research was supported by grants from the National Natural Science Foundation of China (30530250 and 30470549 toL.X.and 30500150 toJ.C.), 973 Program (2006CB500808 to L.X. and J.C.), Science and Technology Foundation of Yunnan Province (2006PT08 to L.X.), and Foundation of Chinese Academy of Science (KSCXI-YW-R-68 to L.X.).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10864]
专题	昆明动物研究所_学习记忆的分子神经机制昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Department of Biology, Yunnan University, Kunming 650021, PR China 2.Key Laboratory of Animal Models and Human Disease Mechanisms, and Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, PR China 3.Graduate School of The Chinese Academy of Sciences, Beijing 100039, PR China 4.Mental Health Institute, the Second Hospital of Central South University, Changsha 410011, PR China 5.Department of Physiology, Kunming Medical College, Kunming 650031, PR China
推荐引用方式 GB/T 7714	Ma WP,Cao J,Yang YX[*],et al. Exposure to chronic constant light impairs spatial memory and influences long-term depression in rats[J]. NEUROSCIENCE RESEARCH,2007,59(2):224-230.
APA	Ma WP.,Cao J.,Yang YX[].,Xu L[].,Tian M.,...&Han HL.(2007).Exposure to chronic constant light impairs spatial memory and influences long-term depression in rats.NEUROSCIENCE RESEARCH,59(2),224-230.
MLA	Ma WP,et al."Exposure to chronic constant light impairs spatial memory and influences long-term depression in rats".NEUROSCIENCE RESEARCH 59.2(2007):224-230.