Interaction between behavioral despair and addictive behaviors in rats

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 学习记忆的分子神经机制

	Interaction between behavioral despair and addictive behaviors in rats
	Tian M 1,3; Mao RR 1; Xu L[]1,2; Wang LP 1; Zhou QX 1; Cao J[]1
刊名	Physiology & Behavior
	2011
卷号	102 期号:X 页码:7-12
关键词	Behavioral despair Addictive behavior Conditioned place preference Forced swim test Morphine
通讯作者	juncao@vip.163.com
英文摘要	It has been suggested that depression can be either a cause or a consequence of drug abuse, providing a possible explanation for the fact that the prevalence of depression is almost 3-fold higher in drug abusers than in the general population. However, the interaction between depression and drug abuse has not been fully elucidated. To examine the interaction between behavioral despair and addictive behaviors, we used the Porsolt's forced swim test (FST) as a model of behavioral despair, and we used morphine conditioned place preference (CPP) and repeated morphine exposure as models of addictive behaviors. We found that rats exposed to a standard FST (15 min on day 0 training) rather than a weak FST (10 min on day 0 training) exhibited behavioral despair, which selectively potentiated morphine CPP (mCPP) but not food CPP (fCPP). The antidepressant imipramine (15 mg/kg, i.p.), which blocked the behavioral despair, prevented the standard FST potentiated morphine CPP. Conversely, repeated exposure to morphine (10 mg/kg, s.c.) for 6, 12 or 20 days decreased, had no effect on, or increased the immobility time, respectively, in the subsequent standard FST. Furthermore, repeated morphine exposure for 20 days exacerbated the pre-existing behavioral despair. Thus, our findings suggest that behavioral despair may increase the vulnerability of individuals to opiate abuse, which may in turn enhance behavioral despair. (C) 2010 Elsevier Inc. All rights reserved.
收录类别	SCI
资助信息	This work was supported by grants from the 973 program of the Ministry of Science and Technology of China (2007CB512303 and 2009CB522006, to JC), and the National Science Foundation of China (30870806 to JC and 30870802 to LX).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10836]
专题	昆明动物研究所_学习记忆的分子神经机制昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming 650223, PR China 2.Mental Health Institute, The 2nd Xiangya Hospital of Central South University, Changsha 410011, PR China 3.Graduate University of Chinese Academy of Sciences, Beijing 100039, PR China
推荐引用方式 GB/T 7714	Tian M,Mao RR,Xu L[*],et al. Interaction between behavioral despair and addictive behaviors in rats[J]. Physiology & Behavior,2011,102(X):7-12.
APA	Tian M,Mao RR,Xu L[],Wang LP,Zhou QX,&Cao J[].(2011).Interaction between behavioral despair and addictive behaviors in rats.Physiology & Behavior,102(X),7-12.
MLA	Tian M,et al."Interaction between behavioral despair and addictive behaviors in rats".Physiology & Behavior 102.X(2011):7-12.