Altered resting-state regional homogeneity after 13 weeks of paliperidone injection treatment in schizophrenia patients

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 学习记忆的分子神经机制

	Altered resting-state regional homogeneity after 13 weeks of paliperidone injection treatment in schizophrenia patients
	Bai Y 1; Wang WX 1; Luo CR 4; Wang LZ 5; Chen XY 1; Shan BC 6; Xu L 7; Xu XF 1; Xu J 2; Cheng YQ[*]1
刊名	Psychiatry Research: Neuroimaging
	2016
卷号	258 期号:X 页码:37–43
关键词	Schizophrenia Paliperidone palmitate Resting state fMRI ReHo Antipsychotics
通讯作者	yuqich@163.com
合作状况	其它
英文摘要	This study aimed to explore the effects of the long-acting antipsychotic drug palmitate paliperidone in resting-state brain activity of schizophrenia patients. Seventeen schizophrenia outpatients were included and received palmitate paliperidone injection (PAL) treatment for 13 weeks. These patients were compared to seventeen matched healthy controls. All subjects underwent two scan sessions of resting-state magnetic resonance imaging (baseline and the 13th week) and regional homogeneity (ReHo) at resting-state where compared. After 13 weeks of treatment, PAL increased ReHo of the prefrontal cortex, anterior cingulate gyrus and orbital frontal gyrus, while PAL decreased ReHo of the thalamus, parahippocampal gyrus and superior temporal gyrus. Furthermore, improvement of psychiatric symptoms correlated with changing amplitude of ReHo: positively correlated with postcentral gyrus and negatively correlated with the occipital cortex. Baseline ReHo values of the middle occipital gyrus were positively correlated with the rate of reduction of psychiatric symptoms and improvement of social function. These results suggested that PAL might achieve its clinical effect in schizophrenia by influencing the resting-state function of the occipital cortex, lateral prefrontal cortex and temporal lobe. Baseline function of the inferior occipital gyrus might potentially predict the short-term effect of PAL in schizophrenia.
收录类别	SCI
资助信息	This work is supported by grants from The National Natural Science Foundation of China (81160379, 81160171, 81460256, 81560233), Middle and Young Aged Academic and Technology Leaders Reserve Personnel Foundation of Yunnan Province (2015HB071).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10642]
专题	昆明动物研究所_学习记忆的分子神经机制昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China 2.Department of Internal Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, China 3.Magnetic Resonance Imaging Center, First Affiliated Hospital of Kunming Medical University, Kunming, China 4.Magnetic Resonance Imaging Center, First Hospital of Kunming City, Kunming, China 5.School of Life Sciences, Tsinghua University, Beijing, China 6.Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China 7.Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, China
推荐引用方式 GB/T 7714	Bai Y,Wang WX,Luo CR,et al. Altered resting-state regional homogeneity after 13 weeks of paliperidone injection treatment in schizophrenia patients[J]. Psychiatry Research: Neuroimaging,2016,258(X):37–43.
APA	Bai Y.,Wang WX.,Luo CR.,Wang LZ.,Chen XY.,...&Yu HJ.(2016).Altered resting-state regional homogeneity after 13 weeks of paliperidone injection treatment in schizophrenia patients.Psychiatry Research: Neuroimaging,258(X),37–43.
MLA	Bai Y,et al."Altered resting-state regional homogeneity after 13 weeks of paliperidone injection treatment in schizophrenia patients".Psychiatry Research: Neuroimaging 258.X(2016):37–43.