Protective effect of APOE epsilon 2 on intrinsic functional connectivity of the entorhinal cortex is associated with better episodic memory in elderly individuals with risk factors for Alzheimer’s disease

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 学习记忆的分子神经机制

	Protective effect of APOE epsilon 2 on intrinsic functional connectivity of the entorhinal cortex is associated with better episodic memory in elderly individuals with risk factors for Alzheimer’s disease
	Chen J 1; Shu H 1; Xu L 2; Zhang ZJ[*]1,3; Wang Z 1; Liu D 1; Shi YM 1
刊名	ONCOTARGET
	2016
卷号	7 期号:37 页码:58789-58801
关键词	Gerotarget amnestic mild cognitive impairment apolipoprotein E entorhinal cortex fMRI functional connectivity
通讯作者	janemengzhang@vip.163.com
英文摘要	The apolipoprotein E (APOE) ε4 allele associates with accelerating the conversion from amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD), whereas the protectiveAPOEε2 allele appears to be against the disease. Moreover, entorhinal cortex (ERC) is one of the earliest brain regions of AD pathology that disrupts the formation of episodic memory. To investigate the effects of APOE ε2 and ε4alleles on functional connectivity (FC) of ERC and cognition in aMCI. Methods The FC analyses of ERC were performed in 83 aMCI (9 ε2-carrier, 44 ε3ε3, and 30 ε4-carrier) and 88 healthy controls (HC, 15 ε2-carrier, 40 ε3ε3, and 33 ε4-carrier). Multiple linear regression model was performed between the altered ERC connectivities and cognition. In the ERC network, aMCI with ε4-carriers showed decreased FC in the bilateral middle temporal gyrus (MTG), right precuneus, and right precentral gyrus (PreCG), while ε2-carriers showed increased FC in these regions (except the right PreCG) compared to HC. The altered FC between ERC and right MTG correlated with episodic memory performance in aMCI carried ε2 and ε4 alleles. These results suggest that the effects ofAPOEon the ERC network are closely linked to the role of this gene on AD risk, which aMCI with ε4-carriers can accelerate the pathological progression of network-based mechanisms while ε2-carriers may play a protective role in contributing to a compensatory mechanism. It further suggests that APOE can appear to directly affect the ERC-MTG neural pathway associated with the impairment of episodic memory in aMCI.
收录类别	SCI
资助信息	This study was supported by the National Natural Science Foundation of China (No. 81420108012, 81500919, and 91432000), the Key Program for Clinical Medicine and Science and Technology, Jiangsu Province (No. BL2013025 and BL2014077), National Key Technology Research and Development Program of the Ministry of Science and Technology of China (Grand No.2015BAI13B01), the Fundamental Research Funds for the Central Universities and the Scientific Research Innovation Program for College and University Graduates of Jiangsu Province (No. KYZZ15_0063), and the Scientific Research Foundation of Graduate School of Southeast University (No. YBJJ1538).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10390]
专题	昆明动物研究所_学习记忆的分子神经机制昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Department of neurology, Affiliated ZhongDa Hospital, Medical School, Southeast University, Nanjing, Jiangsu, PR China 2.Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming, Yunnan, China 3.Department of Psychology, Xinxiang Medical University, Xinxiang, Henan, China
推荐引用方式 GB/T 7714	Chen J,Shu H,Xu L,et al. Protective effect of APOE epsilon 2 on intrinsic functional connectivity of the entorhinal cortex is associated with better episodic memory in elderly individuals with risk factors for Alzheimer’s disease[J]. ONCOTARGET,2016,7(37):58789-58801.
APA	Chen J.,Shu H.,Xu L.,Zhang ZJ[*].,Wang Z.,...&Shi YM.(2016).Protective effect of APOE epsilon 2 on intrinsic functional connectivity of the entorhinal cortex is associated with better episodic memory in elderly individuals with risk factors for Alzheimer’s disease.ONCOTARGET,7(37),58789-58801.
MLA	Chen J,et al."Protective effect of APOE epsilon 2 on intrinsic functional connectivity of the entorhinal cortex is associated with better episodic memory in elderly individuals with risk factors for Alzheimer’s disease".ONCOTARGET 7.37(2016):58789-58801.