Unilateral hippocampal inactivation or lesion selectively impairs remote contextual fear memory

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 学习记忆的分子神经机制

	Unilateral hippocampal inactivation or lesion selectively impairs remote contextual fear memory
	Zhou H 1,2; Zhou QX[]2; Xu L[]2,3
刊名	PSYCHOPHARMACOLOGY
	2016
卷号	233 期号:19-20 页码:3639-3646
关键词	Bilateral hippocampus Fear memory Recent memory Remote memory Unilateral hippocampus
通讯作者	qixin_zhou@126.com ; lxu@vip.163.com
合作状况	其它
英文摘要	RATIONALE: Contextual fear memory depends on the hippocampus, but the role of unilateral hippocampus in this type of memory remains unclear. OBJECTIVES: Herein, pharmacological inactivation or excitotoxic lesions were used to study the role of unilateral hippocampus in the stages of contextual fear memory. RESULTS: The pharmacological experiments revealed that compared with the control groups, unilateral hippocampal blockade did not impair 1-day recent memory following learning, whereas bilateral hippocampal blockade significantly impaired this memory. The lesion experiments showed that compared with the control groups, the formed contextual fear memory was retained for 7 days and that 30-day remote memory was markedly reduced in unilateral hippocampal lesion groups. CONCLUSIONS: These results indicate that an intact bilateral hippocampus is required for the formation of remote memory and that unilateral hippocampus is sufficient for recent contextual fear memory.
收录类别	SCI
资助信息	This work was supported by the National Basic Research Program of China from the Ministry of Science and Technology of China (2013CB835103 to L.X.), the Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002 to L.X.), the National Science Foundation of China (31371141 to Q.-X. Z.), and the Science and Technology Program of Yunnan Province (2013GA003 to L.X.).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10355]
专题	昆明动物研究所_学习记忆的分子神经机制昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, People’s Republic of China 2.Laboratory of Learning and Memory, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, CAS, Kunming 650223, People’s Republic of China 3.Kunming College of Life Sciences, University of Chinese Academy of Sciences, Kunming, People’s Republic of China
推荐引用方式 GB/T 7714	Zhou H,Zhou QX[],Xu L[]. Unilateral hippocampal inactivation or lesion selectively impairs remote contextual fear memory[J]. PSYCHOPHARMACOLOGY,2016,233(19-20):3639-3646.
APA	Zhou H,Zhou QX[],&Xu L[].(2016).Unilateral hippocampal inactivation or lesion selectively impairs remote contextual fear memory.PSYCHOPHARMACOLOGY,233(19-20),3639-3646.
MLA	Zhou H,et al."Unilateral hippocampal inactivation or lesion selectively impairs remote contextual fear memory".PSYCHOPHARMACOLOGY 233.19-20(2016):3639-3646.