Opposite Effective Connectivity in the Posterior Cingulate and Medial Prefrontal Cortex between First-Episode Schizophrenic Patients with Suicide Risk and Healthy Controls

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 学习记忆的分子神经机制

	Opposite Effective Connectivity in the Posterior Cingulate and Medial Prefrontal Cortex between First-Episode Schizophrenic Patients with Suicide Risk and Healthy Controls
	Zhang HR 1,3; Wei XM[*]2; Tao HJ 1; Mwansisya TE 1,4; Pu WD 1; He Z 5; Hu AM 1; Xu L 6; Liu ZN 1; Shan BC 2
刊名	PLOS ONE
	2013
卷号	8 期号:5 页码:e63477
通讯作者	zningl@163.com ; x.zhimin@163.com
合作状况	其它
英文摘要	Objective: The schizophrenic patients with high suicide risk are characterized by depression, better cognitive function, and prominent positive symptoms. However, the neurobiological basis of suicide attempts in schizophrenia is not clear. The suicide in schizophrenia is implicated in the defects in emotional process and decision-making, which are associated with prefrontal-cingulate circuit. In order to explore the possible neurobiological basis of suicide in schizophrenia, we investigated the correlation of prefrontal-cingulate circuit with suicide risk in schizophrenia via dynamic casual modelling. Method: Participants were 33 first-episode schizophrenic patients comprising of a high suicide risk group (N = 14) and a low suicide risk group (N = 19). A comparison group of healthy controls (N = 15) were matched for age, gender and education. N-back tasking functional magnetic resonance imaging data was collected. Results: Compared with healthy controls group, the two patients groups showed decreased task-related suppression during 2-back task state versus baseline state in the left posterior cingulate and medial prefrontal cortex; the hyper-connectivity from the left posterior cingulate cortex to the left medial prefrontal cortex existed in both schizophrenic patients groups, but hypo-connectivity in the opposite direction only existed in the schizophrenic patients group with high suicide risk. Conclusions: The hyper-connectivity from the left posterior cingulate cortex to the left medial prefrontal cortex may suggest that the abnormal effective connectivity was associated with risk for schizophrenia. The hypo-connectivity in the opposite direction may represent a possible correlate of increased vulnerability to suicide attempt.
收录类别	SCI
资助信息	This work was supported by the National Natural Science Foundation of China (81171287, 30971053 to Dr. Zhimin Xue, and 81271485, 81071092 to Dr. Z. Liu), the National 973 Program of China (2011CB707800 to Dr. Zhening Liu), and Specialized Research Fund for the Doctoral Program of Higher Education (20110162110017 to Dr. Zhening Liu).
语种	英语
WOS记录号	WOS:000319330200043
公开日期	2013-07-05
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7559]
专题	昆明动物研究所_学习记忆的分子神经机制昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Mental Health Institute of The Second Xiangya Hospital, Central South University, Changsha, China 2.Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China 3.Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China 4.Department of Clinical Nursing and Community Health, the University of Dodoma, Dodoma, Tanzania 5.Department of Radiology of The Second Xiangya Hospital, Central South University, Changsha, China 6.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
推荐引用方式 GB/T 7714	Zhang HR,Wei XM[*],Tao HJ,et al. Opposite Effective Connectivity in the Posterior Cingulate and Medial Prefrontal Cortex between First-Episode Schizophrenic Patients with Suicide Risk and Healthy Controls[J]. PLOS ONE,2013,8(5):e63477.
APA	Zhang HR.,Wei XM[].,Tao HJ.,Mwansisya TE.,Pu WD.,...&Xue ZM[].(2013).Opposite Effective Connectivity in the Posterior Cingulate and Medial Prefrontal Cortex between First-Episode Schizophrenic Patients with Suicide Risk and Healthy Controls.PLOS ONE,8(5),e63477.
MLA	Zhang HR,et al."Opposite Effective Connectivity in the Posterior Cingulate and Medial Prefrontal Cortex between First-Episode Schizophrenic Patients with Suicide Risk and Healthy Controls".PLOS ONE 8.5(2013):e63477.