Frontal and cingulate gray matter volume reduction in heroin dependence: Optimized voxel-based morphometry

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 学习记忆的分子神经机制

	Frontal and cingulate gray matter volume reduction in heroin dependence: Optimized voxel-based morphometry
	Liu HH 1; Hao YH 1; Kaneko Y 2; Ouyang X 1; Zhang Y 1; Xu L 1,3; Xue ZM[]1; Liu ZN[]1
刊名	PSYCHIATRY AND CLINICAL NEUROSCIENCES
	2009
卷号	63 期号:4 页码:563-568
关键词	brain imaging gray matter heroin voxel-based morphometry
ISSN号	1323-1316
通讯作者	x.zhimin@163.com
合作状况	其它
英文摘要	Aims: Repeated exposure to heroin, a typical opiate, causes neuronal adaptation and may result in anatomical changes in specific brain regions, particularly the frontal and limbic cortices. The volume changes of gray matter (GM) of these brain regions, however, have not been identified in heroin addiction. Methods: Using structural magnetic resonance imaging and an optimized voxel-based morphometry approach, the GM volume difference between 15 Chinese heroin-dependent and 15 healthy subjects was tested. Results: Compared to healthy subjects, the heroin-dependent subjects had reduced GM volume in the right prefrontal cortex, left supplementary motor cortex and bilateral cingulate cortices. Conclusion: Frontal and cingulate atrophy may be involved in the neuropathology of heroin dependence.
收录类别	SCI
资助信息	The work was supported by grants from the National Natural Science Foundation of China (30530250 to Lin Xu) and 973 Program (2006CB500800 to Lin Xu and 2007CB512308 to Zhening Liu).
原文出处	2009634563.pdf
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/5931]
专题	昆明动物研究所_学习记忆的分子神经机制昆明动物研究所_动物模型与人类重大疾病机理重点实验室
作者单位	1.Mental Health Institute, Second Xiangya Hospital of Central South University, Changsha, Hunan 2.Yale University School of Medicine, New Haven, Connecticut, USA 3.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology of Chinese Academy of Science, Kuming, Yunnan, Chin
推荐引用方式 GB/T 7714	Liu HH,Hao YH,Kaneko Y,et al. Frontal and cingulate gray matter volume reduction in heroin dependence: Optimized voxel-based morphometry[J]. PSYCHIATRY AND CLINICAL NEUROSCIENCES,2009,63(4):563-568.
APA	Liu HH.,Hao YH.,Kaneko Y.,Ouyang X.,Zhang Y.,...&Liu ZN[*].(2009).Frontal and cingulate gray matter volume reduction in heroin dependence: Optimized voxel-based morphometry.PSYCHIATRY AND CLINICAL NEUROSCIENCES,63(4),563-568.
MLA	Liu HH,et al."Frontal and cingulate gray matter volume reduction in heroin dependence: Optimized voxel-based morphometry".PSYCHIATRY AND CLINICAL NEUROSCIENCES 63.4(2009):563-568.