Peripheral administration of kisspeptin antagonist does not alter basal plasma testosterone but decreases plasma adiponectin levels in adult male rhesus macaques

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	Peripheral administration of kisspeptin antagonist does not alter basal plasma testosterone but decreases plasma adiponectin levels in adult male rhesus macaques
	Huma T[*]1,2; Ulla F 1; Hanif F 1; Rizak JD 2; Shahab M 1
刊名	TURKISH JOURNAL OF BIOLOGY
	2014
卷号	38 期号:4 页码:450-456
关键词	rhesus monkey adiponectin reproduction Kisspeptin peptide 234 testosterone
通讯作者	tanzeelhuma@gmail.com
合作状况	其它
英文摘要	Kisspeptin signaling is a potent regulator of the reproductive axis and an elicitor of gonadotropin-releasing hormone secretion. The present study assessed the effect of the peripheral administration of a kisspeptin antagonist (P234) on testosterone secretion in the adult male rhesus monkey. Five monkeys were administered with either P234 (38.8 mu g/kg body weight) or a vehicle (0.9% saline). Plasma testosterone and adiponectin levels, as a positive control, were then measured using specific ELISA assays from blood samples collected sequentially at 15-min intervals from 60 min prior to until 360 min after the P234/vehicle injection. In 3 monkeys, the experiment was repeated where the animals received a kisspeptin-10 (50 mu g) challenge 30 min after the P234 or vehicle treatment. No effects on basal testosterone levels were found after the systemic administration of P234. Plasma adiponectin levels were found to be briefly decreased by P234. P234 administration was found to suppress kisspeptin-dependent testosterone release and to inhibit kisspeptin-dependent adiponectin release. This suggested that the systemic administration of P234 was effective peripherally. However, the minimal peripheral effects on testosterone secretion in the male macaque suggested that P234 did not cross the blood-brain barrier and blocked the peripheral kisspeptin receptors.
收录类别	SCI
资助信息	This study was funded by the Higher Education Commission (HEC) of Pakistan through an indigenous PhD scholarship to Tanzeel Huma.
语种	英语
WOS记录号	WOS:000337274500003
公开日期	2014-10-16
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/8063]
专题	昆明动物研究所_神经系统编码
作者单位	1.Laboratory of Reproductive Neuroendocrinology, Department of Animal Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan 2.Key State Laboratory of Brain and Cognitive Science, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, Yunnan, P.R. China
推荐引用方式 GB/T 7714	Huma T[*],Ulla F,Hanif F,et al. Peripheral administration of kisspeptin antagonist does not alter basal plasma testosterone but decreases plasma adiponectin levels in adult male rhesus macaques[J]. TURKISH JOURNAL OF BIOLOGY,2014,38(4):450-456.
APA	Huma T[*],Ulla F,Hanif F,Rizak JD,&Shahab M.(2014).Peripheral administration of kisspeptin antagonist does not alter basal plasma testosterone but decreases plasma adiponectin levels in adult male rhesus macaques.TURKISH JOURNAL OF BIOLOGY,38(4),450-456.
MLA	Huma T[*],et al."Peripheral administration of kisspeptin antagonist does not alter basal plasma testosterone but decreases plasma adiponectin levels in adult male rhesus macaques".TURKISH JOURNAL OF BIOLOGY 38.4(2014):450-456.