How does the motor relearning program improve neurological function of brain ischemia monkeys?**

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	How does the motor relearning program improve neurological function of brain ischemia monkeys?**
	Yin Y 1; Gu Z 2; Pan L 1; Gan L 1; Qin DD 3; Yang B 4; Guo J 5; Hu XT 3; Wang TH 6; Feng ZT[*]6
刊名	NEURAL REGENERATION RESEARCH
	2013
卷号	8 期号:16 页码:1445-1454
关键词	neural regeneration brain injury stroke grants-supported paper neuroregeneration motor relearning program rhesus macaque brain ischemia animal model neurological function neurotrophic factor single-photon emission CT cerebral blood flow
通讯作者	zhongtangfeng@sina.com
合作状况	其它
英文摘要	The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. In injured brain tissues, glial fibrillary acidic protein and neurofilament protein changes can reflect the condition of injured neurons and astrocytes, while vascular endothelial growth factor and basic fibroblast growth factor changes can indicate angiogenesis. In the present study, we induced ischemic brain injury in the rhesus macaque by electrocoagulation of the M1 segment of the right middle cerebral artery. The motor relearning program was conducted for 60 days from the third day after model establishment. Immunohistochemistry and single-photon emission CT showed that the numbers of glial fibrillary acidic protein-, neurofilament protein-, vascular endothelial growth factor- and basic fibroblast growth factor-positive cells were significantly increased in the infarcted side compared with the contralateral hemisphere following the motor relearning program. Moreover, cerebral blood flow in the infarcted side was significantly improved. The clinical rating scale for stroke was used to assess neurological function changes in the rhesus macaque following the motor relearning program. Results showed that motor function was improved, and problems with consciousness, self-care ability and balance function were significantly ameliorated. These findings indicate that the motor relearning program significantly promoted neuronal regeneration, repair and angiogenesis in the surroundings of the infarcted hemisphere, and improve neurological function in the rhesus macaque following brain ischemia.
收录类别	SCI
资助信息	This study was supported by the Combined Specific Foundation of Department of Science and Technology of Yunnan Province and Kunming Medical University, No. 2008CD037.
语种	英语
公开日期	2013-07-18
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7575]
专题	昆明动物研究所_神经系统编码
作者单位	1.Department of Rehabilitation Medicine, Fourth Hospital of Kunming Medical University, Kunming 650021, Yunnan Province, China 2.Department of Neurosurgery, Fourth Hospital of Kunming Medical University, Kunming 650021, Yunnan Province, China 3.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan Province, China 4.Department of Nuclear Medicine, Fourth Hospital of Kunming Medical University, Kunming 650021, Yunnan Province, China 5.Department of Pathology, Fourth Hospital of Kunming Medical University, Kunming 650021, Yunnan Province, China 6.Institute of Neuroscience, Kunming Medical University, Kunming 650500, Yunnan Province, China
推荐引用方式 GB/T 7714	Yin Y,Gu Z,Pan L,et al. How does the motor relearning program improve neurological function of brain ischemia monkeys?**[J]. NEURAL REGENERATION RESEARCH,2013,8(16):1445-1454.
APA	Yin Y.,Gu Z.,Pan L.,Gan L.,Qin DD.,...&Feng ZT[].(2013).How does the motor relearning program improve neurological function of brain ischemia monkeys?*.NEURAL REGENERATION RESEARCH,8(16),1445-1454.
MLA	Yin Y,et al."How does the motor relearning program improve neurological function of brain ischemia monkeys?**".NEURAL REGENERATION RESEARCH 8.16(2013):1445-1454.