Combined action of MK-801 and ceftriaxone impairs the acquisition and reinstatement of morphine-induced conditioned place preference, and delays morphine extinction in rats

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	Combined action of MK-801 and ceftriaxone impairs the acquisition and reinstatement of morphine-induced conditioned place preference, and delays morphine extinction in rats
	Fan YD 1,3,5; Niu HC 2; Rizak JD 3; Li L 4; Wang GM 4; Xu LQ 4; Ren H 4; Lei H[]2; Yu HL[]5
刊名	NEUROSCIENCE BULLETIN
	2012
卷号	28 期号:5 页码:567-576
关键词	ceftriaxone conditioned place preference morphine MK-801 glutamate transporter subtype-1
通讯作者	leihao@wipm.ac.cn ; yuhl308@126.com
合作状况	其它
英文摘要	It is well established that glutamate and its receptors, particularly the N-methyl-D-aspartate receptor (NMDAR), play a significant role in addiction and that the inhibition of glutamatergic hyperfunction reduces addictive behaviors in experimental animals. Specifically, NMDAR antagonists such as MK-801, and an inducer of the expression of glutamate transporter subtype-1 (GLT-1) (ceftriaxone) are known to inhibit addictive behavior. The purpose of this study was to determine whether the combined action of a low dose of MK-801 and a low dose of ceftriaxone provides better inhibition of the acquisition, extinction, and reinstatement of morphine-induced conditioned place preference (CPP) than either compound alone. A morphine-paired CPP experiment was used to study the effects of low doses of MK-801, ceftriaxone and a combination of both on reward-related memory (acquisition, extinction, and reinstatement of morphine preference) in rats. A low dose of neither MK-801 (0.05 mg/kg, i.p.) nor ceftriaxone (25 mg/kg, i.p.) alone effectively impaired CPP behaviors. However, when applied in combination, they reduced the acquisition of morphine-induced CPP and completely prevented morphine reinstatement. Their combination also notably impaired the extinction of morphine-induced CPP. The combined action of a low dose of an NMDAR antagonist (MK-801) and GLT-1 activation by ceftriaxone effectively changed different phases of CPP behavior
收录类别	SCI
资助信息	This work was supported by grants from the National Basic Research Develop- ment Program (973 Program) of China (2011CB707802, 2011CB707800) and the National Natural Science Founda- tion of China (81171302).
语种	英语
WOS记录号	WOS:000309357800012
公开日期	2012-11-06
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7126]
专题	昆明动物研究所_神经系统编码
作者单位	1.Department of Neurosurgery, the Third Affi liated Hospital of Kunming Medical University, Kunming 650118, China 2.State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Math- ematics, Chinese Academy of Sciences, Wuhan 430071, China 3.State Key Laboratory of Brain and Cognitive Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 4.Department of Medical Imaging, Kunming General Hospital of Chengdu Military Region, People's Liberation Army, Kunming 650032, China 5.Minimally Invasive Neurosurgery Department, the First Affi liated Hospital of Kunming Medical University, Kunming 650032, China
推荐引用方式 GB/T 7714	Fan YD,Niu HC,Rizak JD,et al. Combined action of MK-801 and ceftriaxone impairs the acquisition and reinstatement of morphine-induced conditioned place preference, and delays morphine extinction in rats[J]. NEUROSCIENCE BULLETIN,2012,28(5):567-576.
APA	Fan YD.,Niu HC.,Rizak JD.,Li L.,Wang GM.,...&Yu HL[*].(2012).Combined action of MK-801 and ceftriaxone impairs the acquisition and reinstatement of morphine-induced conditioned place preference, and delays morphine extinction in rats.NEUROSCIENCE BULLETIN,28(5),567-576.
MLA	Fan YD,et al."Combined action of MK-801 and ceftriaxone impairs the acquisition and reinstatement of morphine-induced conditioned place preference, and delays morphine extinction in rats".NEUROSCIENCE BULLETIN 28.5(2012):567-576.