Anxiety- and depressive-like behaviors in olfactory deficient Cnga2 knockout mice

	Anxiety- and depressive-like behaviors in olfactory deficient Cnga2 knockout mice
	Chen YM 1; Liu XF 3; Jia XL 1; Zong W 2; Ma YY 2; Xu FQ[]4; Wang JH[]2
刊名	BEHAVIOURAL BRAIN RESEARCH
	2014
卷号	275 期号:X 页码:219-224
关键词	Olfactory Depression Anxiety Olfactory deficient
通讯作者	fuqiang.xu@wipm.ac.cn ; wjh16@hotmail.com
合作状况	其它
英文摘要	There is a close neuroanatomical connection between odor and emotional processing. Olfactory dysfunction is found in various neurodegenerative and neuropsychiatric disorders. Here, mice take the cyclic nucleotide gated channel 2 mutant gene (Cnga2), which is critical for olfactory sensory neurons to generate odor induced action potentials were used. The Cnga2 mice were congenitally anosmic. Adult mice were tested in a series behavioral paradigm such as open field, light/dark box, forced swim test and Y-maze. Our study found that Cnga2 mice showed increased anxiety- and depressive-like behaviors than their wide type siblings. However, Cnga2 mice showed no difference from the wide types when tested in the two-trial recognition Y-maze. The results indicate that innate olfactory deficiency might modulate emotional behaviors in mice.
收录类别	SCI
资助信息	This study was supported by The State Major Research Project of China (2012CB825500, 2011CB707800), the National Science Foundation of China (NSFC 31271168, 91132307, 813111172). The Fundamental Research Funds for the Central Universities for Jichuan Zhang and the Research Foundation of Kunming University of Science and Technology (KKSY201360114).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/9254]
专题	昆明动物研究所_认知障碍病理学昆明动物研究所_动物模型与人类重大疾病机理重点实验室昆明动物研究所_神经系统编码
作者单位	1.Medical Faculty, Kunming University of Science and Technology, Kunming Yunnan 650550, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 3.Department of Physiology, Bengbu Medical College, Bengbu, Anhui, 233030, China 4.State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, the Chinese Academy of Sciences, Wuhan 430007, China
推荐引用方式 GB/T 7714	Chen YM,Liu XF,Jia XL,et al. Anxiety- and depressive-like behaviors in olfactory deficient Cnga2 knockout mice[J]. BEHAVIOURAL BRAIN RESEARCH,2014,275(X):219-224.
APA	Chen YM.,Liu XF.,Jia XL.,Zong W.,Ma YY.,...&Wang JH[*].(2014).Anxiety- and depressive-like behaviors in olfactory deficient Cnga2 knockout mice.BEHAVIOURAL BRAIN RESEARCH,275(X),219-224.
MLA	Chen YM,et al."Anxiety- and depressive-like behaviors in olfactory deficient Cnga2 knockout mice".BEHAVIOURAL BRAIN RESEARCH 275.X(2014):219-224.