Anatomical MRI templates of tree shrew brain for volumetric analysis and voxel-based morphometry

	Anatomical MRI templates of tree shrew brain for volumetric analysis and voxel-based morphometry
	Wang SX 1,2; Shan D 1,2; Dai JK 1,2; Niu HC 1,2; Ma YY 3; Lin FC 1; Lei H[*]1
刊名	JOURNAL OF NEUROSCIENCE METHODS
	2013
卷号	220 期号:1 页码:9-17
关键词	Tree shrew Brain Magnetic resonance imaging Template Volumetric measurement
通讯作者	leihao@wipm.ac.cn
合作状况	其它
英文摘要	Background: Tree shrews are close relatives of primates, and are increasingly used as models in the research of vision, social stress and neurological/psychiatric diseases. However, neuroimaging techniques, for example magnetic resonance (MR) imaging, are only rarely applied to this species to study the structure and function of the brain. A template MR image set, which is essential for morphometry/volumetric analysis, of tree shrew brain has been lacking in the literature. New method: High-resolution anatomical MR images and diffusion tensor images of the brain were acquired from male Chinese tree shrews (Tupaia belangeri chinensis), and resampled to an isotropic resolution of 200 mu m x 200 mu m x 200 mu m. Population-based image templates of tree shrew brain, including gray matter/white matter/cerebrospinal fluid probability maps and a fractional anisotropy template, were constructed at this spatial resolution, all in a reference space. Digital masks of representative anatomical structures, including hippocampus, amygdala and cingulum bundle, were created. Result: With the templates constructed, the volumes of bilateral hippocampus and amygdala were measured using a template-facilitated semi-automated approach to be 59.8 +/- 8.3 and 64.3 +/- 3.4 mm(3), respectively. Comparison with existing method(s): For the first time, high-resolution MR image templates of tree shrew brain were reported. The average volume of bilateral hippocampus measured with the template-facilitated semi-automated approach was found to be similar to the result obtained by the much more labor-intensive manual approach. Conclusions: The MR image templates obtained in this study are useful for analyzing neuroimage data of tree shrew brain. The templates are freely available to the scientific community upon request.
收录类别	SCI
资助信息	This work was supported by grants from Chinese Ministry of Science and Technology (2011CB707800) and Natural Science Foundation of China (81171302 and 21221064).
语种	英语
WOS记录号	WOS:000326429900002
公开日期	2013-11-29
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/7715]
专题	昆明动物研究所_认知障碍病理学
作者单位	1.Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China 2.Graduate University of Chinese Academy of Sciences, Beijing, China 3.Laboratory of Primate Neurosciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
推荐引用方式 GB/T 7714	Wang SX,Shan D,Dai JK,et al. Anatomical MRI templates of tree shrew brain for volumetric analysis and voxel-based morphometry[J]. JOURNAL OF NEUROSCIENCE METHODS,2013,220(1):9-17.
APA	Wang SX.,Shan D.,Dai JK.,Niu HC.,Ma YY.,...&Lei H[*].(2013).Anatomical MRI templates of tree shrew brain for volumetric analysis and voxel-based morphometry.JOURNAL OF NEUROSCIENCE METHODS,220(1),9-17.
MLA	Wang SX,et al."Anatomical MRI templates of tree shrew brain for volumetric analysis and voxel-based morphometry".JOURNAL OF NEUROSCIENCE METHODS 220.1(2013):9-17.