Chronic morphine treatment decreases acoustic startle response and prepulse inhibition in rats

	Chronic morphine treatment decreases acoustic startle response and prepulse inhibition in rats
	Meng ZQ 1,3; Zhou DM 1,2; Wang JH 1; Ma YY[*]1,2
刊名	SCIENCE CHINA-LIFE SCIENCES
	2010
卷号	53 期号:11 页码:1356-1360
关键词	morphine treatment sensorimotor gating startle response prepulse inhibition
通讯作者	yuanma0716@vip.sina.com
合作状况	其它
英文摘要	The reward-related effects of addictive drugs primarily act via the dopamine system, which also plays an important role in sensorimotor gating. The mesolimbic dopamine system is the common pathway of drug addiction and sensorimotor gating. However, the way in which addictive drugs affect sensorimotor gating is currently unclear. In previous studies, we examined the effects of morphine treatment on sensory gating in the hippocampus. The present study investigated the effects of morphine on sensorimotor gating in rats during chronic morphine treatment and withdrawal. Rats were examined during treatment with morphine for 10 successive days, followed by a withdrawal period. Acoustic startle responses to a single startle stimulus (115 dB SPL) and prepulse inhibition responses were recorded. The results showed that acoustic startle responses were attenuated during morphine treatment, but not during withdrawal. PPI was impaired in the last 2 morphine treatment days, but returned to a normal level during withdrawal.
收录类别	SCI
资助信息	This work was supported by the National Natural Science Foundation of China (Grant Nos. 30470553, 30770700 and 30530270), National High-Tech Research and Development Program of China (Grant No. O7013810), Major State Basic Research Development Program of China (Grant Nos. 2005CB522803 and 2007CB947703) and Yunnan Science and Technology Program (Grant No. 2006PT08-2).
语种	英语
公开日期	2010-12-17
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/353002/6544]
专题	昆明动物研究所_认知障碍病理学昆明动物研究所_神经系统编码
作者单位	1.State Key Laboratory of Brain and Cognitive Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China 3.Graduate University of Chinese Academy of Sciences, Beijing 100049, China
推荐引用方式 GB/T 7714	Meng ZQ,Zhou DM,Wang JH,et al. Chronic morphine treatment decreases acoustic startle response and prepulse inhibition in rats[J]. SCIENCE CHINA-LIFE SCIENCES,2010,53(11):1356-1360.
APA	Meng ZQ,Zhou DM,Wang JH,&Ma YY[*].(2010).Chronic morphine treatment decreases acoustic startle response and prepulse inhibition in rats.SCIENCE CHINA-LIFE SCIENCES,53(11),1356-1360.
MLA	Meng ZQ,et al."Chronic morphine treatment decreases acoustic startle response and prepulse inhibition in rats".SCIENCE CHINA-LIFE SCIENCES 53.11(2010):1356-1360.