Environmental enrichment and chronic restraint stress in ICR mice: Effects on prepulse inhibition of startle and Y-maze spatial recognition memory

	Environmental enrichment and chronic restraint stress in ICR mice: Effects on prepulse inhibition of startle and Y-maze spatial recognition memory
	Chen YM 1,2; Mao Y 1,2; Zhou DM 1; Hu XT 1,3; Wang JH[]1; Ma YY[]1,3
刊名	BEHAVIOURAL BRAIN RESEARCH
	2010
卷号	212 期号:1 页码:49-55
关键词	Enriched environment Restraint stress Prepulse inhibition Y-maze
ISSN号	0166-4328
通讯作者	wjh16@hotmail.com ; yuanma0716@vip.sina.com
合作状况	其它
英文摘要	In most studies regarding the improving or therapeutical effects induced by enriched environment (EE), EE was performed after the stress treatment or in patients with certain diseases. In the current study, the effects of chronic restraint stress (6 h/day) in mice living in an enriched environment or standard environment (SE) were tested. Mice were randomly divided into 4 groups: non-stressed or stressed mice housed in SE or EE conditions (SE, stress + SE, EE, stress + EE). Prepulse inhibition (PPI) of startle was tested after the 2 weeks or 4 weeks stress and/or EE treatment and 1 or 2 weeks withdrawal from the 4 weeks treatment. After the 4 weeks treatment, spatial recognition memory in Y-maze was also tested. The results showed that EE increased PPI in stressed and non-stressed mice after 2 weeks treatment. No effect of EE on PPI was found after the 4 weeks treatment. 4 weeks chronic restraint stress increased PPI in mice housed in standard but not EE conditions. Stressed mice showed deficits on the 1 h delay version of the Y-maze which could be prevented by living in an enriched environment. Our results indicated that living in an enriched environment reversed the impairing effects of chronic restraint stress on spatial recognition memory. However, EE did not change the effects of stress on PPI.
收录类别	SCI
资助信息	This work was supported by the National Basic Research Program of China (973 Program) (2009CB119200) and the National Natural Science Foundation of China (30770168).
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/5499]
专题	昆明动物研究所_认知障碍病理学昆明动物研究所_神经系统编码
作者单位	1.State Key Laboratory of Brain and Cognitive Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, #32 Jiao Chang Dong Lu, Kunming, Yunnan, 650223, PR China 2.Graduate University of Chinese Academy of Sciences, Beijing, PR China 3.State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, PR China
推荐引用方式 GB/T 7714	Chen YM,Mao Y,Zhou DM,et al. Environmental enrichment and chronic restraint stress in ICR mice: Effects on prepulse inhibition of startle and Y-maze spatial recognition memory[J]. BEHAVIOURAL BRAIN RESEARCH,2010,212(1):49-55.
APA	Chen YM,Mao Y,Zhou DM,Hu XT,Wang JH[],&Ma YY[].(2010).Environmental enrichment and chronic restraint stress in ICR mice: Effects on prepulse inhibition of startle and Y-maze spatial recognition memory.BEHAVIOURAL BRAIN RESEARCH,212(1),49-55.
MLA	Chen YM,et al."Environmental enrichment and chronic restraint stress in ICR mice: Effects on prepulse inhibition of startle and Y-maze spatial recognition memory".BEHAVIOURAL BRAIN RESEARCH 212.1(2010):49-55.