Postsynaptic alpha-2 receptor stimulation improves memory in aged monkeys: Indirect effects of yohimbine versus direct effects of clonidine

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	Postsynaptic alpha-2 receptor stimulation improves memory in aged monkeys: Indirect effects of yohimbine versus direct effects of clonidine
	Arnsten AFT 1; Cai JX 2
刊名	NEUROBIOLOGY OF AGING
	1993
卷号	14 期号:6 页码:597-603
关键词	SKF104856 SKF104078 PREFRONTAL CORTEX AGING PRIMATES NOREPINEPHRINE ALPHA-2 ADRENOCEPTORS DELAYED RESPONSE TASK
ISSN号	0197-4580
合作状况	其它
英文摘要	Very low doses (0.00001 mg/kg) of the alpha-2 adrenergic antagonist, yohimbine, improved working memory performance in a subset of aged monkeys. Improvement appeared to result from increased norepinephrine (NE) release onto postsynaptic alpha-2 adrenoceptors, as the response was blocked by the ''postsynaptic'' alpha-2 antagonist, SKF104078. Cognitive-enhancing effects of low dose yohimbine treatment may depend on aged animals retaining an intact, endogenous NE system. In contrast to yohimbine, the alpha-2 agonist, clonidine, has improved working memory in air aged animals examined. In the present study, clonidine's beneficial effects were also blocked by the postsynaptic antagonists SKF104078 and SKF104856, suggesting that clonidine acts by directly stimulating postsynaptic alpha-2 adrenoceptors. Beneficial doses of clonidine (0.01 mg/kg) and yohimbine (0.00001 mg/kg) were combined to see if they would produce additive effects on memory enhancement. This strategy was successful in young monkeys with intact NE systems but was not effective in the aged monkeys. These findings demonstrate that drugs that indirectly stimulate postsynaptic alpha-2 receptors by increasing NE release are not as reliable in aged monkeys as directly acting agonists that can replace NE at postsynaptic alpha-2 receptors.
收录类别	SCI
原文出处	199314597.pdf
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/5055]
专题	昆明动物研究所_其他
作者单位	1.Section of Neurobiology, Yale Medical School, 333 Cedar Street, New Haven, CT 06510-8001, USA 2.Kunming Institute of Zoology, Academia Sinica, Kunming, Yunnan, China 650223
推荐引用方式 GB/T 7714	Arnsten AFT,Cai JX. Postsynaptic alpha-2 receptor stimulation improves memory in aged monkeys: Indirect effects of yohimbine versus direct effects of clonidine[J]. NEUROBIOLOGY OF AGING,1993,14(6):597-603.
APA	Arnsten AFT,&Cai JX.(1993).Postsynaptic alpha-2 receptor stimulation improves memory in aged monkeys: Indirect effects of yohimbine versus direct effects of clonidine.NEUROBIOLOGY OF AGING,14(6),597-603.
MLA	Arnsten AFT,et al."Postsynaptic alpha-2 receptor stimulation improves memory in aged monkeys: Indirect effects of yohimbine versus direct effects of clonidine".NEUROBIOLOGY OF AGING 14.6(1993):597-603.