Functional effects of a retained ancestral polymorphism in prestin

CORC > 昆明动物研究所 > 昆明动物研究所 > 遗传资源与进化国家重点实验室 > 进化与功能基因组学

	Functional effects of a retained ancestral polymorphism in prestin
	Li YY 1,2; Liu Z[]1; Qi FY 1; Zhou X 1; Shi P[]1,3
刊名	Molecular Biology and Evolution
	2016
卷号	34 期号:1 页码:88–92
关键词	SLC26A5 bat echolocation hemiplasy homoplasy
通讯作者	zhenliu@mail.kiz.ac.cn ; ship@mail.kiz.ac.cn
合作状况	其它
英文摘要	Molecular basis for mammalian echolocation has been receiving much concerns. Recent findings on the parallel evolution of prestin sequences among echolocating bats and toothed whales suggest that adaptations for high-frequency hearing have occurred during the evolution of echolocation. Here, we report that although the species tree for echolocating bats emitting echolocation calls with frequency modulated (FM) sweeps is paraphyletic, prestin exhibits similar functional changes between FM bats. Site-directed mutagenesis shows that the amino acid 308S in FM bats is responsible for the similar functional changes of prestin We strongly support that the occurrence of serine at position 308 is a case of hemiplasy, caused by incomplete lineage sorting of an ancestral polymorphism. Our study not only reveals sophisticated molecular basis of echolocation in bats, also calls for caution in the inference of molecular convergence in species experiencing rapid radiation.
收录类别	SCI
资助信息	The project was supported by the “Strategic Priority Research Program” of the Chinese Academy of Sciences (Grant No. XDB13020400), Yunnan province, High-end Scientific and Technological Talents program (2013HA020) and the National Natural Science Foundation of China (31321002, 31325013，31301013).
语种	英语
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/10579]
专题	昆明动物研究所_进化与功能基因组学昆明动物研究所_遗传资源与进化国家重点实验室
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Chin 2.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, China 3.School of Future Technology, University of Chinese Academy of Sciences, Beijing, China
推荐引用方式 GB/T 7714	Li YY,Liu Z[*],Qi FY,et al. Functional effects of a retained ancestral polymorphism in prestin[J]. Molecular Biology and Evolution,2016,34(1):88–92.
APA	Li YY,Liu Z[],Qi FY,Zhou X,&Shi P[].(2016).Functional effects of a retained ancestral polymorphism in prestin.Molecular Biology and Evolution,34(1),88–92.
MLA	Li YY,et al."Functional effects of a retained ancestral polymorphism in prestin".Molecular Biology and Evolution 34.1(2016):88–92.